MS 15203
Chemical Name: 5-[(2-Methyl-1-oxo-2-propen-1-yl)amino]-1,3-benzenedicarboxylic acid
Purity: ≥98%
Biological Activity
MS 15203 is a potent and selective GPR171 partial agonist (EC50 = 90 nM; 28% inhibition of Forskolin activated adenylyl cyclase activity in rat hypothalamic membranes). Exhibits minimal binding to a panel of ~70 GPCRs and 10 other receptors (<22% of radioligand displaced from the target receptors). Increases neuronal activity in the paraventricular nucleus. Increases food intake and body weight in mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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![[D-p-Cl-Phe6,Leu17]-VIP | CAS No. 102805-45-8 | Selective VIP receptor antagonist](https://resources.rndsystems.com/images/datasheets/structures/d-p-cl-phe6-leu17-vip_3054.png "[D-p-Cl-Phe6,Leu17]-VIP | CAS No. 102805-45-8 | Selective VIP receptor antagonist")
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Background References
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Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake
Wardman et al.
Sci.Signal., 2016;9
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