Forskolin

Catalog # Availability Size / Price Qty
1099/10
1099/50
Cat.No. 1099 - Forskolin | C22H34O7 | CAS No. 66575-29-9
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Description: Adenylyl cyclase activator

Chemical Name: [3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one

Purity: ≥98%

Product Details
Citations (63)
Reviews (1)

Biological Activity

Cell-permeable activator of adenylyl cyclase. Hypotensive and vasodilatory agent. Induces neuronal differentiation in stem cells and in several neuroblastoma. Used to reprogram mouse embryonic fibroblasts to induced pluripotent stem cells in combination with three other small molecules (Cat. Nos. 3742, 4423 and 4703).

Available as part of the PKA Tocriset™. Negative Control also available.

Technical Data

M.Wt:
410.51
Formula:
C22H34O7
Solubility:
Soluble to 10 mM in ethanol and to 25 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
66575-29-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Citations for Forskolin

The citations listed below are publications that use Tocris products. Selected citations for Forskolin include:

63 Citations: Showing 1 - 10

  1. Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson�s disease.
    Authors: Tozzi Et al.
    Cell Death Dis  2018;9(2):204
  2. CRISPR-based chromatin remodeling of the endogenous Oct4 or Sox2 locus enables reprogramming to pluripotency.
    Authors: Liu Et al.
    Cell Stem Cell.  2018;22:252
  3. Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane.
    Authors: Burdyga Et al.
    Proc Natl Acad Sci U S A.  2018;115(28):E6497
  4. Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression.
    Authors: Li Et al.
    Theranostics  2017;7:4671
  5. β2-adrenoreceptor Inverse Agonist Down-regulates Muscarine Cholinergic Subtype-3 Receptor and Its Downstream Signal Pathways in Airway Smooth Muscle Cells in vitro.
    Authors: Luo
    Scientific Reports  2017;7:39905
  6. Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling
    Authors: Avanzato Et al.
    Scientific Reports  2016;6:32602
  7. ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model.
    Authors: Chan Et al.
    Cell  2016;6:26119
  8. Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory.
    Authors: Havekes Et al.
    J Neurosci  2016;36:8936
  9. Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability.
    Authors: Pattabiraman Et al.
    Science  2016;351:aad3680
  10. New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling.
    Authors: Brust Et al.
    Cell Rep  2015;93:85
  11. Cyclic Adenosine 3',5'-Monophosphate Elevation and Biological Signaling through a Secretin Family Gs-Coupled G Protein-Coupled Receptor Are Restricted to a Single Adenylate Cyclase Isoform.
    Authors: Emery Et al.
    J Cell Mol Med  2015;87:928
  12. The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.
    Authors: Baron Et al.
    Sci Rep  2015;6:e1629
  13. Optodynamic simulation of β-adrenergic receptor signalling.
    Authors: Siuda Et al.
    Eneuro  2015;6:8480
  14. The short-chain fatty acid receptor GPR43 is transcriptionally regulated by XBP1 in human monocytes.
    Authors: Ang Et al.
    Ann Clin Transl Neurol  2015;5:8134
  15. Increased biogenesis of glucagon-containing secretory granules and glucagon secretion in BIG3-knockout mice.
    Authors: Li Et al.
    Mol Pharmacol  2015;4:246
  16. The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor.
    Authors: Broadbent Et al.
    Sci Rep  2015;467:1783
  17. Retroactive modulation of spike timing-dependent plasticity by dopamine.
    Authors: Brzosko Et al.
    Elife  2015;4
  18. Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist.
    Authors: Presley Et al.
    Biochem Pharmacol  2015;3:e00159
  19. Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
    Authors: Zhu Et al.
    Pharmacol Res Perspect  2015;35:621
  20. Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B.
    Authors: Muñoz-Llancao Et al.
    Biochim Biophys Acta  2015;35:11315
  21. Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP.
    Authors: Elliott Et al.
    Am J Physiol Endocrinol Metab  2015;308:E130
  22. A second trigeminal CGRP receptor: function and expression of the AMY1 receptor.
    Authors: Walker Et al.
    Nat Commun  2015;2:595
  23. Compartmentalized accumulation of cAMP near complexes of multidrug resistance protein 4 (MRP4) and cystic fibrosis transmembrane conductance regulator (CFTR) contributes to drug-induced diarrhea.
    Authors: Moon Et al.
    J Biol Chem  2015;290:11246
  24. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
    Authors: Polito Et al.
    J Neurosci  2015;2
  25. Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization.
    Authors: Jansen Et al.
    Stem Cell Reports  2015;19:210
  26. Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells.
    Authors: Parnell Et al.
    Mol Metab  2015;1853:1749
  27. Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor.
    Authors: Cooke Et al.
    Cell Death Dis  2015;172:593
  28. A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity.
    Authors: Ben-Simon Et al.
    Pflugers Arch  2015;12:396
  29. Inversion of Sonic hedgehog action on its canonical pathway by electrical activity.
    Authors: Belgacem and Borodinsky
    Eur J Neurosci  2015;112:4140
  30. Prostaglandin E2 promotes features of replicative senescence in chronically activated human CD8+ T cells.
    Authors: Chou Et al.
    PLoS One  2014;9:e99432
  31. GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization.
    Authors: Adelfinger Et al.
    Biochem Pharmacol  2014;91:369
  32. PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling.
    Authors: Yang Et al.
    J Biol Chem  2014;66:83
  33. PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues.
    Authors: Felizola Et al.
    Glia  2014;52:159
  34. Derivation and expansion of PAX7-positive muscle progenitors from human and mouse embryonic stem cells.
    Authors: Shelton Et al.
    Br J Pharmacol  2014;3:516
  35. A method to identify and isolate pluripotent human stem cells and mouse epiblast stem cells using lipid body-associated retinyl ester fluorescence.
    Authors: Muthusamy Et al.
    Stem Cell Reports  2014;3:169
  36. Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a TRPP2 (polycystin-2)-dependent manner.
    Authors: Waheed Et al.
    Br J Pharmacol  2014;171:2659
  37. The spatio-temporal dynamics of PKA activity profile during mitosis and its correlation to chromosome segregation.
    Authors: Vandame Et al.
    Cell Cycle  2014;13:3232
  38. cAMP level modulates scleral collagen remodeling, a critical step in the development of myopia.
    Authors: Tao Et al.
    Br J Pharmacol  2013;8:e71441
  39. Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(βγ) subunits in human embryonic kidney 293T cells.
    Authors: Ehrlich Et al.
    Mol Pharmacol  2013;84:476
  40. Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCFβTRCP ubiquitin E3 ligase.
    Authors: Wiseman Et al.
    J Biol Chem  2013;288:17803
  41. Cyclic AMP stimulates neurite outgrowth of lamprey reticulospinal neurons without substantially altering their biophysical properties.
    Authors: Pale Et al.
    Neuroscience  2013;245:74
  42. Age-dependent regulation of synaptic connections by dopamine D2 receptors.
    Authors: Jia Et al.
    Nat Neurosci  2013;16:1627
  43. Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons.
    Authors: Sohn Et al.
    J Mol Endocrinol  2013;152:612
  44. Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice.
    Authors: Korboukh Et al.
    J Med Chem  2012;55:6467
  45. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    Nature  2012;492:123
  46. Dopaminergic modulation of ganglion-cell photoreceptors in rat.
    Authors: Hook Et al.
    J Neurosci  2012;35:507
  47. Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
    Authors: Kaufman Et al.
    J Neurosci  2012;32:3992
  48. AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor.
    Authors: Bolognini Et al.
    Br J Pharmacol  2012;165:2561
  49. A new cannabinoid CB2 receptor agonist HU-910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury.
    Authors: Horváth Et al.
    J Neurosci  2012;165:2462
  50. Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory circuits adapting to inactivity.
    Authors: Mitra Et al.
    Nat Neurosci  2012;15:250
  51. Dynamic mass redistribution assays decode surface influence on signaling of endogenous purinergic P2Y receptors.
    Authors: Tran Et al.
    Assay Drug Dev Technol  2012;10:37
  52. Nitric oxide inhibits highly selective sodium channels and the Na+/K+-ATPase in H441 cells.
    Authors: Althaus Et al.
    Am J Respir Cell Mol Biol  2011;44:53
  53. cAMP response element-binding protein is a primary hub of activity-driven neuronal gene expression.
    Authors: Benito Et al.
    J Neurosci  2011;31:18237
  54. Dual Phosphorylation of suppressor of fused (Sufu) by PKA and GSK3beta regulates its stability and localization in the primary cilium.
    Authors: Chen Et al.
    J Biol Chem  2011;286:13502
  55. Mouse embryonic retina delivers information controlling cortical neurogenesis.
    Authors: Bonetti and Surace
    J Mol Cell Cardiol  2010;5:e15211
  56. A putative 'pre-nervous' endocannabinoid system in early echinoderm development.
    Authors: Buznikov Et al.
    Dev Neurosci  2010;32:1
  57. Dopamine-dependent tuning of striatal inhibitory synaptogenesis.
    Authors: Goffin Et al.
    PLoS One  2010;30:2935
  58. Neuroligin 1 is dynamically exchanged at postsynaptic sites.
    Authors: Schapitz Et al.
    J Neurosci  2010;30:12733
  59. Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.
    Authors: Garavaglia Et al.
    BMC Neurosci  2010;11:7
  60. Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity.
    Authors: Byrnes Et al.
    J Clin Invest  2009;57:550
  61. PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells.
    Authors: Roscioni Et al.
    Respir Res  2009;10:88
  62. Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons.
    Authors: Rao Et al.
    PLoS One  2007;117:4022
  63. Identification of a novel human eicosanoid receptor coupled to G(i/o).
    Authors: Hosoi Et al.
    J Biol Chem  2002;277:31459

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a potent adenylyl cyclase
By Anonymous on 02/21/2018
Species: Rat

Forskolin activates adenylyl cyclase and increases intracellular cAMP. We used at 10 microM in cultured astrocytes to increase intracellular cAMP level.


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