Forskolin

  ( 62 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1099
Chemical Name:[3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
Product Details
Citations (62)
Reviews
Biological Activity
Cell-permeable activator of adenylyl cyclase. Hypotensive and vasodilatory agent. Induces neuronal differentiation in stem cells and in several neuroblastoma. Used to reprogram mouse embryonic fibroblasts to induced pluripotent stem cells in combination with three other small molecules (Cat. Nos. 3742, 4423 and 4703).

Available as part of the PKA Tocriset™. Negative Control also available.

Technical Data
  • M.Wt:
    410.51
  • Formula:
    C22H34O7
  • Solubility:
    Soluble to 10 mM in ethanol and to 25 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    66575-29-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Forskolin include:

62 Citations: Showing 1 - 10
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  1. Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson�s disease.
    Authors: Tozzi Et al.
    Cell Death Dis  2018;9(2):204
  2. CRISPR-based chromatin remodeling of the endogenous Oct4 or Sox2 locus enables reprogramming to pluripotency.
    Authors: Liu Et al.
    Cell Stem Cell.  2018;22:252
  3. Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression.
    Authors: Li Et al.
    Theranostics  2017;7:4671
  4. β2-adrenoreceptor Inverse Agonist Down-regulates Muscarine Cholinergic Subtype-3 Receptor and Its Downstream Signal Pathways in Airway Smooth Muscle Cells in vitro.
    Authors: Luo
    Scientific Reports  2017;7:39905
  5. Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling
    Authors: Avanzato Et al.
    Scientific Reports  2016;6:32602
  6. ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model.
    Authors: Chan Et al.
    Cell  2016;6:26119
  7. Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory.
    Authors: Havekes Et al.
    J Neurosci  2016;36:8936
  8. Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability.
    Authors: Pattabiraman Et al.
    Science  2016;351:aad3680
  9. New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling.
    Authors: Brust Et al.
    Cell Rep  2015;93:85
  10. Cyclic Adenosine 3',5'-Monophosphate Elevation and Biological Signaling through a Secretin Family Gs-Coupled G Protein-Coupled Receptor Are Restricted to a Single Adenylate Cyclase Isoform.
    Authors: Emery Et al.
    J Cell Mol Med  2015;87:928
  11. The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.
    Authors: Baron Et al.
    Sci Rep  2015;6:e1629
  12. Optodynamic simulation of β-adrenergic receptor signalling.
    Authors: Siuda Et al.
    Eneuro  2015;6:8480
  13. The short-chain fatty acid receptor GPR43 is transcriptionally regulated by XBP1 in human monocytes.
    Authors: Ang Et al.
    Ann Clin Transl Neurol  2015;5:8134
  14. Increased biogenesis of glucagon-containing secretory granules and glucagon secretion in BIG3-knockout mice.
    Authors: Li Et al.
    Mol Pharmacol  2015;4:246
  15. The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor.
    Authors: Broadbent Et al.
    Sci Rep  2015;467:1783
  16. Retroactive modulation of spike timing-dependent plasticity by dopamine.
    Authors: Brzosko Et al.
    Elife  2015;4
  17. Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist.
    Authors: Presley Et al.
    Biochem Pharmacol  2015;3:e00159
  18. Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
    Authors: Zhu Et al.
    Pharmacol Res Perspect  2015;35:621
  19. Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B.
    Authors: Muñoz-Llancao Et al.
    Biochim Biophys Acta  2015;35:11315
  20. Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP.
    Authors: Elliott Et al.
    Am J Physiol Endocrinol Metab  2015;308:E130
  21. A second trigeminal CGRP receptor: function and expression of the AMY1 receptor.
    Authors: Walker Et al.
    Nat Commun  2015;2:595
  22. Compartmentalized accumulation of cAMP near complexes of multidrug resistance protein 4 (MRP4) and cystic fibrosis transmembrane conductance regulator (CFTR) contributes to drug-induced diarrhea.
    Authors: Moon Et al.
    J Biol Chem  2015;290:11246
  23. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
    Authors: Polito Et al.
    J Neurosci  2015;2
  24. Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization.
    Authors: Jansen Et al.
    Stem Cell Reports  2015;19:210
  25. Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells.
    Authors: Parnell Et al.
    Mol Metab  2015;1853:1749
  26. Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor.
    Authors: Cooke Et al.
    Cell Death Dis  2015;172:593
  27. A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity.
    Authors: Ben-Simon Et al.
    Pflugers Arch  2015;12:396
  28. Inversion of Sonic hedgehog action on its canonical pathway by electrical activity.
    Authors: Belgacem and Borodinsky
    Eur J Neurosci  2015;112:4140
  29. Prostaglandin E2 promotes features of replicative senescence in chronically activated human CD8+ T cells.
    Authors: Chou Et al.
    PLoS One  2014;9:e99432
  30. GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization.
    Authors: Adelfinger Et al.
    Biochem Pharmacol  2014;91:369
  31. PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling.
    Authors: Yang Et al.
    J Biol Chem  2014;66:83
  32. PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues.
    Authors: Felizola Et al.
    Glia  2014;52:159
  33. Derivation and expansion of PAX7-positive muscle progenitors from human and mouse embryonic stem cells.
    Authors: Shelton Et al.
    Br J Pharmacol  2014;3:516
  34. A method to identify and isolate pluripotent human stem cells and mouse epiblast stem cells using lipid body-associated retinyl ester fluorescence.
    Authors: Muthusamy Et al.
    Stem Cell Reports  2014;3:169
  35. Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a TRPP2 (polycystin-2)-dependent manner.
    Authors: Waheed Et al.
    Br J Pharmacol  2014;171:2659
  36. The spatio-temporal dynamics of PKA activity profile during mitosis and its correlation to chromosome segregation.
    Authors: Vandame Et al.
    Cell Cycle  2014;13:3232
  37. cAMP level modulates scleral collagen remodeling, a critical step in the development of myopia.
    Authors: Tao Et al.
    Br J Pharmacol  2013;8:e71441
  38. Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(βγ) subunits in human embryonic kidney 293T cells.
    Authors: Ehrlich Et al.
    Mol Pharmacol  2013;84:476
  39. Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCFβTRCP ubiquitin E3 ligase.
    Authors: Wiseman Et al.
    J Biol Chem  2013;288:17803
  40. Cyclic AMP stimulates neurite outgrowth of lamprey reticulospinal neurons without substantially altering their biophysical properties.
    Authors: Pale Et al.
    Neuroscience  2013;245:74
  41. Age-dependent regulation of synaptic connections by dopamine D2 receptors.
    Authors: Jia Et al.
    Nat Neurosci  2013;16:1627
  42. Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons.
    Authors: Sohn Et al.
    J Mol Endocrinol  2013;152:612
  43. Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice.
    Authors: Korboukh Et al.
    J Med Chem  2012;55:6467
  44. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    Nature  2012;492:123
  45. Dopaminergic modulation of ganglion-cell photoreceptors in rat.
    Authors: Hook Et al.
    J Neurosci  2012;35:507
  46. Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
    Authors: Kaufman Et al.
    J Neurosci  2012;32:3992
  47. AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor.
    Authors: Bolognini Et al.
    Br J Pharmacol  2012;165:2561
  48. A new cannabinoid CB2 receptor agonist HU-910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury.
    Authors: Horváth Et al.
    J Neurosci  2012;165:2462
  49. Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory circuits adapting to inactivity.
    Authors: Mitra Et al.
    Nat Neurosci  2012;15:250
  50. Dynamic mass redistribution assays decode surface influence on signaling of endogenous purinergic P2Y receptors.
    Authors: Tran Et al.
    Assay Drug Dev Technol  2012;10:37
  51. Nitric oxide inhibits highly selective sodium channels and the Na+/K+-ATPase in H441 cells.
    Authors: Althaus Et al.
    Am J Respir Cell Mol Biol  2011;44:53
  52. cAMP response element-binding protein is a primary hub of activity-driven neuronal gene expression.
    Authors: Benito Et al.
    J Neurosci  2011;31:18237
  53. Dual Phosphorylation of suppressor of fused (Sufu) by PKA and GSK3beta regulates its stability and localization in the primary cilium.
    Authors: Chen Et al.
    J Biol Chem  2011;286:13502
  54. Mouse embryonic retina delivers information controlling cortical neurogenesis.
    Authors: Bonetti and Surace
    J Mol Cell Cardiol  2010;5:e15211
  55. A putative 'pre-nervous' endocannabinoid system in early echinoderm development.
    Authors: Buznikov Et al.
    Dev Neurosci  2010;32:1
  56. Dopamine-dependent tuning of striatal inhibitory synaptogenesis.
    Authors: Goffin Et al.
    PLoS One  2010;30:2935
  57. Neuroligin 1 is dynamically exchanged at postsynaptic sites.
    Authors: Schapitz Et al.
    J Neurosci  2010;30:12733
  58. Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.
    Authors: Garavaglia Et al.
    BMC Neurosci  2010;11:7
  59. Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity.
    Authors: Byrnes Et al.
    J Clin Invest  2009;57:550
  60. PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells.
    Authors: Roscioni Et al.
    Respir Res  2009;10:88
  61. Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons.
    Authors: Rao Et al.
    PLoS One  2007;117:4022
  62. Identification of a novel human eicosanoid receptor coupled to G(i/o).
    Authors: Hosoi Et al.
    J Biol Chem  2002;277:31459
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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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