Catalog Number: 1099
Chemical Name: [3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
Biological Activity
Cell-permeable activator of adenylyl cyclase. Hypotensive and vasodilatory agent. Induces neuronal differentiation in stem cells and in several neuroblastoma. Used to reprogram mouse embryonic fibroblasts to induced pluripotent stem cells in combination with three other small molecules (Cat. Nos. 3742, 4423 and 4703). Also available as part of the PKA Tocriset™.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in ethanol and to 25 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Interactions of forskolin and adenylate cyclase.
    Awad et al.
    J.Biol.Chem., 1983;258:2960
  2. Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?
    Laurenza et al.
    TiPS, 1989;10:442
  3. Structure-activity relationships for activation of adenylate cyclase by the diterpene forskolin and its derivatives.
    Seamon et al.
    J.Med.Chem., 1983;26:436
  4. cAMP induces neuronal differentiation of mesenchymal stem cells via activation of extracellular signal-regulated kinase/MAPK.
    Kim et al.
    Neuroreport, 2005;16:1357
  5. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds.
    Hou et al.
    , 2013;341:651

The citations listed below are publications that use Tocris products. Selected citations for Forskolin include:

Showing Results 1 - 10 of 52

  1. Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells�via�cAMP signaling
    Authors: Avanzato Et al.
    Scientific Reports
  2. ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model.
    Authors: Chan Et al.
  3. New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling.
    Authors: Brust Et al.
    Cell Rep
  4. Cyclic Adenosine 3',5'-Monophosphate Elevation and Biological Signaling through a Secretin Family Gs-Coupled G Protein-Coupled Receptor Are Restricted to a Single Adenylate Cyclase Isoform.
    Authors: Emery Et al.
    J Cell Mol Med
  5. The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.
    Authors: Baron Et al.
    Sci Rep
  6. Optodynamic simulation of β-adrenergic receptor signalling.
    Authors: Siuda Et al.
  7. The short-chain fatty acid receptor GPR43 is transcriptionally regulated by XBP1 in human monocytes.
    Authors: Ang Et al.
    Ann Clin Transl Neurol
  8. Increased biogenesis of glucagon-containing secretory granules and glucagon secretion in BIG3-knockout mice.
    Authors: Li Et al.
    Mol Pharmacol
  9. Retroactive modulation of spike timing-dependent plasticity by dopamine.
    Authors: Brzosko Et al.
  10. The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor.
    Authors: Broadbent Et al.
    Sci Rep
  11. Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist.
    Authors: Presley Et al.
    Biochem Pharmacol
  12. Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
    Authors: Zhu Et al.
    Pharmacol Res Perspect
  13. Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B.
    Authors: Muñoz-Llancao Et al.
    Biochim Biophys Acta
  14. Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP.
    Authors: Elliott Et al.
    Am J Physiol Endocrinol Metab
  15. A second trigeminal CGRP receptor: function and expression of the AMY1 receptor.
    Authors: Walker Et al.
    Nat Commun
  16. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
    Authors: Polito Et al.
    J Neurosci
  17. Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization.
    Authors: Jansen Et al.
    Stem Cell Reports
  18. Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells.
    Authors: Parnell Et al.
    Mol Metab
  19. Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor.
    Authors: Cooke Et al.
    Cell Death Dis
  20. A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity.
    Authors: Ben-Simon Et al.
    Pflugers Arch
  21. Inversion of Sonic hedgehog action on its canonical pathway by electrical activity.
    Authors: Belgacem and Borodinsky
    Eur J Neurosci
  22. Prostaglandin E2 promotes features of replicative senescence in chronically activated human CD8+ T cells.
    Authors: Chou Et al.
    PLoS One
  23. GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization.
    Authors: Adelfinger Et al.
    Biochem Pharmacol
  24. PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling.
    Authors: Yang Et al.
    J Biol Chem
  25. PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues.
    Authors: Felizola Et al.
  26. Derivation and expansion of PAX7-positive muscle progenitors from human and mouse embryonic stem cells.
    Authors: Shelton Et al.
    Br J Pharmacol
  27. A method to identify and isolate pluripotent human stem cells and mouse epiblast stem cells using lipid body-associated retinyl ester fluorescence.
    Authors: Muthusamy Et al.
    Stem Cell Reports
  28. Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a TRPP2 (polycystin-2)-dependent manner.
    Authors: Waheed Et al.
    Br J Pharmacol
  29. The spatio-temporal dynamics of PKA activity profile during mitosis and its correlation to chromosome segregation.
    Authors: Vandame Et al.
    Cell Cycle
  30. cAMP level modulates scleral collagen remodeling, a critical step in the development of myopia.
    Authors: Tao Et al.
    Br J Pharmacol
  31. Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(βγ) subunits in human embryonic kidney 293T cells.
    Authors: Ehrlich Et al.
    Mol Pharmacol
  32. Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCFβTRCP ubiquitin E3 ligase.
    Authors: Wiseman Et al.
    J Biol Chem
  33. Cyclic AMP stimulates neurite outgrowth of lamprey reticulospinal neurons without substantially altering their biophysical properties.
    Authors: Pale Et al.
  34. Age-dependent regulation of synaptic connections by dopamine D2 receptors.
    Authors: Jia Et al.
    Nat Neurosci
  35. Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons.
    Authors: Sohn Et al.
    J Mol Endocrinol
  36. Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice.
    Authors: Korboukh Et al.
    J Med Chem
  37. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
  38. Dopaminergic modulation of ganglion-cell photoreceptors in rat.
    Authors: Hook Et al.
    J Neurosci
  39. Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
    Authors: Kaufman Et al.
    J Neurosci
  40. AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor.
    Authors: Bolognini Et al.
    Br J Pharmacol
  41. A new cannabinoid CB2 receptor agonist HU-910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury.
    Authors: Horváth Et al.
    J Neurosci
  42. Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory circuits adapting to inactivity.
    Authors: Mitra Et al.
    Nat Neurosci
  43. Dynamic mass redistribution assays decode surface influence on signaling of endogenous purinergic P2Y receptors.
    Authors: Tran Et al.
    Assay Drug Dev Technol
  44. Mouse embryonic retina delivers information controlling cortical neurogenesis.
    Authors: Bonetti and Surace
    J Mol Cell Cardiol
  45. A putative 'pre-nervous' endocannabinoid system in early echinoderm development.
    Authors: Buznikov Et al.
    Dev Neurosci
  46. Dopamine-dependent tuning of striatal inhibitory synaptogenesis.
    Authors: Goffin Et al.
    PLoS One
  47. Neuroligin 1 is dynamically exchanged at postsynaptic sites.
    Authors: Schapitz Et al.
    J Neurosci
  48. Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.
    Authors: Garavaglia Et al.
    BMC Neurosci
  49. Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity.
    Authors: Byrnes Et al.
    J Clin Invest
  50. PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells.
    Authors: Roscioni Et al.
    Respir Res
  51. Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons.
    Authors: Rao Et al.
    PLoS One
  52. Identification of a novel human eicosanoid receptor coupled to G(i/o).
    Authors: Hosoi Et al.
    J Biol Chem
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