Narciclasine

Catalog # Availability Size / Price Qty
3715/1
Narciclasine | CAS No. 29477-83-6 | Other Rho GTPase Compounds
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Description: Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression

Chemical Name: (2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Exhibits antiproliferative and pro-apoptotic effects in carcinoma cells and displays cytotoxic activity against a panel of 60 cancer cell lines (mean IC50 = 47 nM). Activity decreases rate of cell division and increases mitosis duration in vitro. Also modulates the Rho/ROCK/LIM kinase/cofilin pathway; stimulates RhoA activation and induces actin polymerization.

Technical Data

M.Wt:
307.26
Formula:
C14H13NO7
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
29477-83-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Narciclasine

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