Exhibits antiproliferative and pro-apoptotic effects in carcinoma cells and displays cytotoxic activity against a panel of 60 cancer cell lines (mean IC50
= 47 nM). Activity decreases rate of cell division and increases mitosis duration in vitro
. Also modulates the Rho/ROCK/LIM kinase/cofilin pathway; stimulates RhoA activation and induces actin polymerization.
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The Amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of the death receptor and/or mitochondrial pathways in cancer cells but not in normal fibroblasts.
Dumont et al.
Structure-activity relationship analysis of novel derivatives of narciclasine (an Amaryllidaceae isocarbostyril derivative) as potential anticancer agents.
Ingrassia et al.
Narciclasine, a plant growth modulator, activates Rho and stress fibers in glioblastoma cells.
Lefranc et al.
Mol.Cancer Ther., 2009;8:1739