Chemical Name: N-[[4-(1-Methylethyl)cyclohexyl]carbonyl]-D-phenylalanine
Biological ActivityKir6 (KATP) blocker. Exhibits in vitro tissue selectivity for pancreatic β-cell-type Kir6 channels over cardiovascular Kir6 channels; displays high affinity for SUR1/Kir6.2 channels. Hypoglycemic agent; stimulates insulin secretion from pancreatic β-cells by increasing cytosolic Ca2+ concentration. Also agonist at the orphan receptor MRGPRX4.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome.
Kroeze et al.
N-(cyclohexylcarbonyl)-D-phenylalanines and related compounds. A new class of hypoglycemic agents.
Shinkai et al.
The ability of a new hypoglycemic agent, A-4166, compared to sulphonylureas, to increase cytosolic Ca2+ in pancreatic beta-cells under metabolic inhibition.
Fujitani et al.
Tissue selectivity of antidiabetic agent nateglinide: study on cardiovascular and β-cell KATP channels.
Hu et al.
Nateglinide, a D-phenylalanine derivative lacking either a sulfonylurea or benzamido moiety, specifically inhibits pancreatic β-cell-type KATP channels.
Chachin et al.
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