) blocker. Exhibits in vitro
tissue selectivity for pancreatic β
6 channels over cardiovascular Kir
6 channels; displays high affinity for SUR1/Kir
6.2 channels. Hypoglycemic agent; stimulates insulin secretion from pancreatic β
-cells by increasing cytosolic Ca2+
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All Tocris products are intended for laboratory research use only.
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Nateglinide, a D-phenylalanine derivative lacking either a sulfonylurea or benzamido moiety, specifically inhibits pancreatic β-cell-type KATP channels.
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N-(cyclohexylcarbonyl)-D-phenylalanines and related compounds. A new class of hypoglycemic agents.
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