Catalog Number: 2924
Chemical Name: 6-S-[(4-Nitrophenyl)methyl]-6-thioinosine
Biological Activity
Equilibrative nucleoside transporter 1 (ENT1) inhibitor (Ki values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).
Technical Data
  • M.Wt:
    419.41
  • Formula:
    C17H17N5O6S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    38048-32-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters, ENT1 and ENT2, stably expressed in nucleoside transporter-deficient PK15 cells.
    Ward et al.
    J.Biol.Chem., 2000;275:8375
  2. Human equilibrative nucleoside transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer.
    Tsujie et al.
    Anticancer Res., 2007;27:2241
  3. Synthesis and flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors.
    Lin and Buolamwini
    J.Med.Chem., 2007;50:3906
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NBMPR include:

2 Citations: Showing 1 - 2
Filter your results:

  1. The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.
    Authors: Baron Et al.
    J Exp Bot 2015;6:e1629
  2. Chronic sleep restriction disrupts sleep homeostasis and behavioral sensitivity to alcohol by reducing the extracellular accumulation of adenosine.
    Authors: Clasadonte Et al.
    J Neurosci 2014;34:1879

Have you used NBMPR?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information