NE 100 hydrochloride

Catalog # Availability Size / Price Qty
3133/10
3133/50
Sigma1 Receptor Antagonists Small Molecule
1 Image
Description: Selective σ1 antagonist

Chemical Name: 4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine hydrochloride

Purity: ≥98%

Product Details
Citations (6)
Reviews

Biological Activity

Potent and selective σ1 receptor antagonist (Ki = 0.86 nM) that displays > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1, D2, 5-HT1A, 5-HT2 and PCP receptors. Exhibits reversible binding (Kd = 1.2 nM) and displays antipsychotic activity in vivo. Orally active.

Technical Data

M.Wt:
391.97
Formula:
C23H33NO2.HCl
Solubility:
Soluble to 25 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
149409-57-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. NE-100, a novel potent σ ligand, preferentially binds to σ1 binding sites in guinea pig brain.
    Chaki et al.
    Eur.J.Pharmacol., 1994;251:R1
  2. NE-100, a novel sigma receptor ligand: in vivo tests.
    Okuyama et al.
    Pharmacol.Letts., 1993;53:PL285
  3. Characteristics of binding of [3H]NE-100, a novel sigma-receptor ligand, to guinea-pig brain membranes.
    Tanaka et al.
    Naunyn Schmied.Arch.Pharmacol., 1995;351:244

Product Datasheets

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Citations for NE 100 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for NE 100 hydrochloride include:

6 Citations: Showing 1 - 6

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