Catalog Number: 3133
Chemical Name: 4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine hydrochloride
Biological Activity
Potent and selective σ1 receptor antagonist (Ki = 0.86 nM) that displays > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1, D2, 5-HT1A, 5-HT2 and PCP receptors. Exhibits reversible binding (Kd = 1.2 nM) and displays antipsychotic activity in vivo. Orally active.
Technical Data
  • M.Wt:
    391.97
  • Formula:
    C23H33NO2.HCl
  • Solubility:
    Soluble to 25 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    149409-57-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. NE-100, a novel potent σ ligand, preferentially binds to σ1 binding sites in guinea pig brain.
    Chaki et al.
    Eur.J.Pharmacol., 1994;251:R1
  2. NE-100, a novel sigma receptor ligand: in vivo tests.
    Okuyama et al.
    Pharmacol.Letts., 1993;53:PL285
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NE 100 hydrochloride include:

3 Citations: Showing 1 - 3
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  1. The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
    Authors: Rodríguez-Muñoz Et al.
    Br J Pharmacol 2015;6:35458
  2. The effects of σ (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice.
    Authors: Malik Et al.
    Int J Neuropsychopharmacol 2015;172:2519
  3. The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
    Authors: Sánchez-Blázquez Et al.
    Eur J Immunol 2014;17:1943

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