NE 100 hydrochloride

Tocris Bioscience | Catalog # 3133

Selective σ1 antagonist
Tocris Bioscience

Key Product Details

Description

Selective σ1 antagonist
View all Sigma1 Receptor Antagonists »

Product Description

NE 100 hydrochloride is a potent and selective σ1 receptor antagonist (Ki = 0.86 nM) that displays > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1, D2, 5-HT1A, 5-HT2 and PCP receptors. Exhibits reversible binding (Kd = 1.2 nM) and displays antipsychotic activity in vivo. Orally active.

Product Specifications for NE 100 hydrochloride

Molecular Weight

391.97

Formula

C23H33NO2.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine hydrochloride

CAS Number

149409-57-4

PubChem ID

9952420

InChI Key

ZHGMDXSHODHWHV-UHFFFAOYSA-N

SMILES

CCCN(CCC)CCC1=CC=C(OC)C(OCCC2=CC=CC=C2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 1.96 5
DMSO 39.2 100

Preparing Stock Solutions for NE 100 hydrochloride

The following data is based on the product molecular weight 391.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.76 mL 25.51 mL
5 mM 0.51 mL 2.55 mL 5.10 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 19 publications citing the usage of this product.

Product Documents for NE 100 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NE 100 hydrochloride

For research use only

Citations for NE 100 hydrochloride

Customer Reviews for NE 100 hydrochloride (1)

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  • It can inhibit sigma1 receptor
    Name: Yuyang Sun
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: sh-sy5y
    Verified Customer | Posted 06/29/2022
    Used it to inhibit sigma 1 receptors. It can inhibit sigma 1 receptor and increase SOCE channels.
    NE 100 hydrochloride 3133

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