Potent and selective σ1
receptor antagonist (Ki
= 0.86 nM) that displays > 55-fold selectivity over σ2
receptors and > 6000-fold selectivity over D1
and PCP receptors. Exhibits reversible binding (Kd
= 1.2 nM) and displays antipsychotic activity in vivo
. Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
NE-100, a novel potent σ ligand, preferentially binds to σ1 binding sites in guinea pig brain.
Chaki et al.
NE-100, a novel sigma receptor ligand: in vivo tests.
Okuyama et al.
The citations listed below are publications that use Tocris products. Selected citations for NE 100 hydrochloride include:
Showing Results 1 - 3 of 3