NE 100 hydrochloride

  ( 5 citations )    
Product Datasheet
Catalog Number:3133
Chemical Name:4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine hydrochloride
Product Details
Citations (5)
Reviews
Biological Activity
Potent and selective σ1 receptor antagonist (Ki = 0.86 nM) that displays > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1, D2, 5-HT1A, 5-HT2 and PCP receptors. Exhibits reversible binding (Kd = 1.2 nM) and displays antipsychotic activity in vivo. Orally active.
Technical Data
  • M.Wt:
    391.97
  • Formula:
    C23H33NO2.HCl
  • Solubility:
    Soluble to 25 mM in water and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    149409-57-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for NE 100 hydrochloride include:

5 Citations: Showing 1 - 5
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  1. Amyloid toxicity is enhanced after pharmacological or genetic invalidation of the σ1 receptor.
    Authors: Maurice
    Behav Brain Res  2017;339:1
  2. The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
    Authors: Rodríguez-Muñoz Et al.
    Br J Pharmacol  2015;6:35458
  3. The effects of σ (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice.
    Authors: Malik Et al.
    Int J Neuropsychopharmacol  2015;172:2519
  4. The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
    Authors: Sánchez-Blázquez Et al.
    Eur J Immunol  2014;17:1943
  5. A 96-well filtration method for radioligand binding analysis of σ receptor ligands.
    Authors: Fishback Et al.
    J Pharm Biomed Anal  2012;71:157

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