NE 100 hydrochloride
Chemical Name: 4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine hydrochloride
Biological ActivityNE 100 hydrochloride is a potent and selective σ1 receptor antagonist (Ki = 0.86 nM) that displays > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1, D2, 5-HT1A, 5-HT2 and PCP receptors. Exhibits reversible binding (Kd = 1.2 nM) and displays antipsychotic activity in vivo. Orally active.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
NE-100, a novel potent σ ligand, preferentially binds to σ1 binding sites in guinea pig brain.
Chaki et al.
NE-100, a novel sigma receptor ligand: in vivo tests.
Okuyama et al.
Characteristics of binding of [3H]NE-100, a novel sigma-receptor ligand, to guinea-pig brain membranes.
Tanaka et al.
Naunyn Schmied.Arch.Pharmacol., 1995;351:244
Citations for NE 100 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for NE 100 hydrochloride include:
6 Citations: Showing 1 - 6
Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy.
Authors: Atzmon Et al.
Front Mol Neurosci 2018;11:336
Amyloid toxicity is enhanced after pharmacological or genetic invalidation of the σ1 receptor.
Behav Brain Res 2017;339:1
The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
Authors: Rodríguez-Muñoz Et al.
Br J Pharmacol 2015;6:35458
The effects of σ (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice.
Authors: Malik Et al.
Int J Neuropsychopharmacol 2015;172:2519
The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
Authors: Sánchez-Blázquez Et al.
Eur J Immunol 2014;17:1943
A 96-well filtration method for radioligand binding analysis of σ receptor ligands.
Authors: Fishback Et al.
J Pharm Biomed Anal 2012;71:157
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