Nilutamide
Chemical Name: 5,5-Dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedione
Purity: ≥99%
Biological Activity
Non-steroidal and silent antiandrogen. Binds to androgen receptors and also inhibits androgen biosynthesis in vitro. In rats in vivo it inhibits androgen-induced prostate weight increase and inhibits negative androgen-dependent gonadotropin feedback leading to an increase in luteinising hormone and testosterone. Orally active.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Inhibition of rat testicular 17-α-hydroxylase and 17,20-lyase activities by anti-androgens (flutamide, hydroxyflutamide, RU23908, cyproterone acetate) in vitro.
Ayub and Levell
J.Steroid Biochem., 1987;28:43 -
Action of a non-steroid anti-androgen, RU 23908, in peripheral and central tissues.
Raynaud et al.
J.Steroid Biochem., 1979;11:93 -
The pure antiandrogen RU 23908 (Anandron), a candidate of choice for the combined antihormonal treatment of prostatic cancer.
Raynaud et al.
The Prostate, 1984;5:299 -
Pharmacology and clinical studies with RU 23908 (Anandron).
Raynaud et al.
Prog.Clin.Biol.Res., 1985;185A:99
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