Catalog Number: 1759
Alternate Names: RU 23908
Chemical Name: 5,5-Dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedione
Biological Activity
Non-steroidal and silent antiandrogen. Binds to androgen receptors and also inhibits androgen biosynthesis in vitro. In rats in vivo it inhibits androgen-induced prostate weight increase and inhibits negative androgen-dependent gonadotropin feedback leading to an increase in luteinising hormone and testosterone. Orally active.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in ethanol with gentle warming and to 25 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibition of rat testicular 17-α-hydroxylase and 17,20-lyase activities by anti-androgens (flutamide, hydroxyflutamide, RU23908, cyproterone acetate) in vitro.
    Ayub and Levell
    J.Steroid Biochem., 1987;28:43
  2. The pure antiandrogen RU 23908 (Anandron), a candidate of choice for the combined antihormonal treatment of prostatic cancer.
    Raynaud et al.
    The Prostate, 1984;5:299
  3. Pharmacology and clinical studies with RU 23908 (Anandron).
    Raynaud et al.
    Prog.Clin.Biol.Res., 1985;185A:99
  4. Action of a non-steroid anti-androgen, RU 23908, in peripheral and central tissues.
    Raynaud et al.
    J.Steroid Biochem., 1979;11:93
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