Nilutamide

Key Product Details

Product Description

Non-steroidal and silent antiandrogen. Binds to androgen receptors and also inhibits androgen biosynthesis in vitro. In rats in vivo it inhibits androgen-induced prostate weight increase and inhibits negative androgen-dependent gonadotropin feedback leading to an increase in luteinising hormone and testosterone. Orally active.

Product Specifications for Nilutamide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Nilutamide

The following data is based on the product molecular weight 317.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	12.61 mL	63.05 mL	126.10 mL
1.25 mM	2.52 mL	12.61 mL	25.22 mL
2.5 mM	1.26 mL	6.30 mL	12.61 mL
12.5 mM	0.25 mL	1.26 mL	2.52 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Raynaud Pharmacology and clinical studies with RU 23908 (Anandron). Prog.Clin.Biol.Res. 1985 PMID: 4034583
• Raynaud Action of a non-steroid anti-androgen, RU 23908, in peripheral and central tissues. J.Steroid Biochem. 1979 PMID: 385986
• Raynaud The pure antiandrogen RU 23908 (Anandron), a candidate of choice for the combined antihormonal treatment of prostatic cancer. The Prostate 1984 PMID: 6374639
• Ayub and Levell Inhibition of rat testicular 17-α-hydroxylase and 17,20-lyase activities by anti-androgens (flutamide, hydroxyflutamide, RU23908, cyproterone acetate) in vitro. J.Steroid Biochem. 1987 PMID: 2956461

Product Documents for Nilutamide