Syk inhibitor. Blocks Aβ
secretion and reduces BACE-1 expression in CHO cells over-expressing Aβ in vitro
. Enhances clearance of Aβ
across the blood brain barrier in vivo
. Reduces brain Aβ
levels in a mouse tauopathy model. Also L-type calcium channel blocker and antihypertensive.
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All Tocris products are intended for laboratory research use only.
The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation.
Paris et al.
Dihydropyrimidines: novel calcium antagonists with potent and long-lasting vasodilative and antihypertensive activity.
Cho et al.