Potent inhibitor of Aβ
oligomer and fibril formation (IC50
= 50 nM for formation of fibrils from Aβ
1-42). Reduces cytotoxicity of Aβ
oligomers and increases cell viability in neuronal cells. Significantly extends lifespan of Drosophila expressing human Aβ
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Atomic and dynamic insights into the beneficial effect of the 1,4-naphthoquinon-2-yl-L-tryptophan inhibitor on Alzheimer's Aβ1-42 dimer in terms of aggregation and toxicity.
Zhang et al.
ACS Chem.Neurosci., 2013;5:148
Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor.
Scherzer-Attali et al.
PLoS ONE, 2010;5:e11101