Catalog Number: 5398
Chemical Name: N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan
Biological Activity
Potent inhibitor of Aβ oligomer and fibril formation (IC50 = 50 nM for formation of fibrils from Aβ1-42). Reduces cytotoxicity of Aβ oligomers and increases cell viability in neuronal cells. Significantly extends lifespan of Drosophila expressing human Aβ1-42.
Technical Data
  • M.Wt:
    360.36
  • Formula:
    C21H16N2O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    185351-19-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor.
    Scherzer-Attali et al.
    PLoS ONE, 2010;5:e11101
  2. Atomic and dynamic insights into the beneficial effect of the 1,4-naphthoquinon-2-yl-L-tryptophan inhibitor on Alzheimer's Aβ1-42 dimer in terms of aggregation and toxicity.
    Zhang et al.
    ACS Chem.Neurosci., 2013;5:148

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