Chemical Name: N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]urea
Biological ActivityKV4.3 channel activator; mediates the transient outward K+ current (Ito). Increases IKv4.3 peak current amplitude in CHO-K1 cells expressing KV4.3 and KChIP2 (EC50 = 5.3 μM). Inhibits KV1.4-mediated currents independently of KChIP2. Also slows the decay of KV4.2 and KV4.3 currents in the presence of KChIP2.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome.
Calloe et al.
Differential effects of the transient outward K+ current activator NS5806 in the canine left ventricle.
Calloe et al.
Effect of the Ito activator NS5806 on cloned Kv4 channels depends on the accessory protein KChIP2.
Lundby et al.
Citation for NS 5806
The citations listed below are publications that use Tocris products. Selected citations for NS 5806 include:
1 Citation: Showing 1 - 1
Modulation of the voltage-gated potassium channel (Kv4.3) and the auxiliary protein (KChIP3) interactions by the current activator NS5806.
Authors: Gonzalez Et al.
J Biol Chem 2014;289:32201
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Reviews for NS 5806
Average Rating: 4 (Based on 1 Review)
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NS 5806 was studied to understand its channel opening properties. The product was dissolved in DMSO and it showed channel opening properties as expected. Performs well in experimental condition. Would recommend and use again.