NS 6180

Catalog # Availability Size / Price Qty
4864/10
4864/50
Cat.No. 4864 - NS 6180 | C16H12F3NOS | CAS No. 353262-04-1
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Description: Potent KCa3.1 channel blocker

Chemical Name: 4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

Potent KCa3.1 channel blocker (IC50 values are 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively). Exhibits ~ 50% inhibition of KCa1.1, KV1.3, and KV11.1 channels, noradrenaline and dopamine transporters, L-type Ca2+ channels and melatonin receptors at a concentration of 10 μM. Potently inhibits IL-2 and IFN-γ production in rat lymphocytes (IC50 ~ 50 nM); reduces DBNS-induced experimental colitis in rats.

Technical Data

M.Wt:
323.33
Formula:
C16H12F3NOS
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
353262-04-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citation for NS 6180

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