NS 6180

Catalog # Availability Size / Price Qty
4864/10
4864/50
Ca2+-Activated Potassium Channel Blockers Small Molecule
1 Image
Description: Potent KCa3.1 channel blocker

Chemical Name: 4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one

Purity: ≥99%

Product Details
Citations (1)
Reviews (1)

Biological Activity

Potent KCa3.1 channel blocker (IC50 values are 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively). Exhibits ~ 50% inhibition of KCa1.1, KV1.3, and KV11.1 channels, noradrenaline and dopamine transporters, L-type Ca2+ channels and melatonin receptors at a concentration of 10 μM. Potently inhibits IL-2 and IFN-γ production in rat lymphocytes (IC50 ~ 50 nM); reduces DBNS-induced experimental colitis in rats.

Technical Data

M.Wt:
323.33
Formula:
C16H12F3NOS
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
353262-04-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for NS 6180

The citations listed below are publications that use Tocris products. Selected citations for NS 6180 include:

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Reviews for NS 6180

Average Rating: 4 (Based on 1 Review)

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Great product to study KV channel blocking activity
By Sadequl Islam on 10/13/2018
Species: Mouse

Product is a great K.v channel blocker. Used in studies to understand the mechanism of action of NS 6180 and its differences with other blocker mechanism. The purchased product showed stability and worked well in the study conditions.Would purchase again


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