NS 6180

Tocris Bioscience | Catalog # 4864

Potent KCa3.1 (IK) channel blocker
Tocris Bioscience
Discontinued Product
4864 has been discontinued. View all Ca2+-Activated Potassium Channel Blockers products.

Key Product Details

Description

Potent KCa3.1 (IK) channel blocker
View all Ca2+-Activated Potassium Channel Blockers »

Product Description

NS 6180 is a potent KCa3.1 channel blocker (IC50 values are 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively). Exhibits ~ 50% inhibition of KCa1.1, KV1.3, and KV11.1 channels, noradrenaline and dopamine transporters, L-type Ca2+ channels and melatonin receptors at a concentration of 10 μM. Potently inhibits IL-2 and IFN-γ production in rat lymphocytes (IC50 ~ 50 nM); reduces DBNS-induced experimental colitis in rats.

Product Specifications for NS 6180

Molecular Weight

323.33

Formula

C16H12F3NOS

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one

CAS Number

353262-04-1

PubChem ID

11837221

InChI Key

ZUIJXKLTUFCDGO-UHFFFAOYSA-N

SMILES

O=C2N(CC3=CC=CC(C(F)(F)F)=C3)C1=CC=CC=C1SC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.33 100
Ethanol 32.33 100

Preparing Stock Solutions for NS 6180

The following data is based on the product molecular weight 323.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.09 mL 15.46 mL 30.93 mL
5 mM 0.62 mL 3.09 mL 6.19 mL
10 mM 0.31 mL 1.55 mL 3.09 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for NS 6180

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NS 6180

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for NS 6180 (1)

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  • Great product to study KV channel blocking activity
    Name: Sadequl Islam
    Species: Mouse
    Assay Type: In Vitro
    Verified Customer | Posted 10/13/2018
    Must be dissloved in DMSO
    Product is a great K.v channel blocker. Used in studies to understand the mechanism of action of NS 6180 and its differences with other blocker mechanism. The purchased product showed stability and worked well in the study conditions.Would purchase again
    NS 6180 4864

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