NSC 109555 ditosylate

Catalog # Availability Size / Price Qty
3034/10
3034/50
NSC 109555 ditosylate | CAS No. 66748-43-4 | Checkpoint Kinase Inhibitors
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Description: Selective Chk2 inhibitor
Alternative Names: DDUG

Chemical Name: 4,4'-diacetyldiphenylurea bis(guanylhydrazone) ditosylate

Purity: ≥98%

Product Details
Citations (3)
Reviews

Biological Activity

Selective, reversible, ATP-competitive Chk2 inhibitor (IC50 = 0.2 μM) that displays no effect on a range of other kinases including Chk1 (IC50 > 10 μM). Inhibits histone H1 phosphorylation (IC50 = 0.24 μM) and attenuates mitochondrial ATP synthesis. Exhibits antiproliferative activity in a number of leukemias in vivo.

Technical Data

M.Wt:
752.86
Formula:
C19H24N10O.2C7H8O3S
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
66748-43-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for NSC 109555 ditosylate

The citations listed below are publications that use Tocris products. Selected citations for NSC 109555 ditosylate include:

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