NSC 109555 ditosylate

Key Product Details

Product Description

NSC 109555 ditosylate is a selective, reversible, ATP-competitive Chk2 inhibitor (IC₅₀ = 0.2 μM) that displays no effect on a range of other kinases including Chk1 (IC₅₀ > 10 μM). Inhibits histone H1 phosphorylation (IC₅₀ = 0.24 μM) and attenuates mitochondrial ATP synthesis. Exhibits antiproliferative activity in a number of leukemias in vivo.

Product Specifications for NSC 109555 ditosylate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NSC 109555 ditosylate

The following data is based on the product molecular weight 752.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.28 mL	66.41 mL	132.83 mL
0.5 mM	2.66 mL	13.28 mL	26.57 mL
1 mM	1.33 mL	6.64 mL	13.28 mL
5 mM	0.27 mL	1.33 mL	2.66 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Byczkowski Potentiation of the antimitochondrial and antiproliferative effects of bis(guanylhydrazones) by phenethylbiguanide. Cancer Res. 1982 PMID: 6896674
• Jobson Identification of a bis-guanylhydrazone [4,4'-diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase. Mol.Pharmacol. 2007 PMID: 17616632
• Byczkowski Actions of bis(guanylhydrazones) on isolated rat liver mitochondria. Biochem.Pharmacol. 1981 PMID: 6895596

Product Documents for NSC 109555 ditosylate