NSC 109555 ditosylate (CAS 66748-43-4): R&D Systems
Catalog Number: 3034
Alternate Names: DDUG
Chemical Name: 4,4'-diacetyldiphenylurea bis(guanylhydrazone) ditosylate
Biological Activity
Selective, reversible, ATP-competitive Chk2 inhibitor (IC50 = 0.2 μM) that displays no effect on a range of other kinases including Chk1 (IC50 > 10 μM). Inhibits histone H1 phosphorylation (IC50 = 0.24 μM) and attenuates mitochondrial ATP synthesis. Exhibits antiproliferative activity in a number of leukemias in vivo.
Technical Data
  • M.Wt:
    752.86
  • Formula:
    C19H24N10O.2C7H8O3S
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    66748-43-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Actions of bis(guanylhydrazones) on isolated rat liver mitochondria.
    Byczkowski et al.
    Biochem.Pharmacol., 1981;30:2851
  2. Potentiation of the antimitochondrial and antiproliferative effects of bis(guanylhydrazones) by phenethylbiguanide.
    Byczkowski et al.
    Cancer Res., 1982;42:3592
  3. Identification of a bis-guanylhydrazone [4,4'-diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase.
    Jobson et al.
    Mol.Pharmacol., 2007;72:876
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NSC 109555 ditosylate include:

2 Citations: Showing 1 - 2
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  1. Inhibition of checkpoint kinase 2 (CHK2) enhances sensitivity of pancreatic adenocarcinoma cells to gemcitabine.
    Authors: Duong Et al.
    J Cell Mol Med 2013;17:1261
  2. The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway.
    Authors: Fard Et al.
    Cell Cycle 2013;13:408

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