NSC 146109 hydrochloride

Tocris Bioscience | Catalog # 2185

Cell-permeable, genotype-selective antitumor agent; activates p53-dependent transcription
Tocris Bioscience
Discontinued Product
2185 has been discontinued. View all p53 Activators products.

Key Product Details

Description

Cell-permeable, genotype-selective antitumor agent; activates p53-dependent transcription
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Product Description

NSC 146109 hydrochloride is a cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Increases levels of endogenous p53 in tumor cells and protects p53 from Mdm2-mediated degradation. Displays some selectivity for tumor cells vs. normal cells in an MTT cell viability assay.

Product Specifications for NSC 146109 hydrochloride

Molecular Weight

316.85

Formula

C17H16N2S.HCl

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

(10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride

CAS Number

59474-01-0

PubChem ID

5458312

InChI Key

VIBMUYOXJUCEMA-UHFFFAOYSA-N

SMILES

N=C(N)SCC1=C(C=CC=C3)C3=C(C)C2=C1C=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.68 100
Ethanol 3.17 10

Preparing Stock Solutions for NSC 146109 hydrochloride

The following data is based on the product molecular weight 316.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.78 mL 31.56 mL
5 mM 0.63 mL 3.16 mL 6.31 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

Product Documents for NSC 146109 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NSC 146109 hydrochloride

For research use only

Citations for NSC 146109 hydrochloride

Customer Reviews for NSC 146109 hydrochloride (1)

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  • p53 activation
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: hela
    Verified Customer | Posted 02/29/2020
    p53-mediated apoptosis after treatment with NSC146109 for 12–16 hours
    NSC 146109 hydrochloride 2185

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