Catalog Number: 2185
Chemical Name: (10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride
Biological Activity
Cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Increases levels of endogenous p53 in tumor cells and protects p53 from Mdm2-mediated degradation. Displays some selectivity for tumor cells vs. normal cells in an MTT cell viability assay.
Technical Data
  • M.Wt:
    316.85
  • Formula:
    C17H16N2S.HCl
  • Solubility:
    Soluble to 10 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    59474-01-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells.
    Dolma et al.
    Cancer Cell, 2003;3:285
  2. Pilot screening programme for small molecule activators of p53.
    Berkson et al.
    Int.J.Cancer, 2005;115:701

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