Cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Increases levels of endogenous p53 in tumor cells and protects p53 from Mdm2-mediated degradation. Displays some selectivity for tumor cells vs. normal cells in an MTT cell viability assay.
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All Tocris products are intended for laboratory research use only.
Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells.
Dolma et al.
Cancer Cell, 2003;3:285
Pilot screening programme for small molecule activators of p53.
Berkson et al.