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NSC 146109 hydrochloride

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2185/50
NSC 146109 hydrochloride | CAS No. 59474-01-0 | p53 Activators
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Description: Cell-permeable, genotype-selective antitumor agent; activates p53-dependent transcription

Chemical Name: (10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride

Purity: ≥99%

Product Details
Citations (1)
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Increases levels of endogenous p53 in tumor cells and protects p53 from Mdm2-mediated degradation. Displays some selectivity for tumor cells vs. normal cells in an MTT cell viability assay.

Technical Data

M.Wt:
316.85
Formula:
C17H16N2S.HCl
Solubility:
Soluble to 10 mM in ethanol and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
59474-01-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for NSC 146109 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for NSC 146109 hydrochloride include:

1 Citation: Showing 1 - 1

  1. Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders.
    Authors: Calo Et al.
    Nature  2018;554:112

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p53 activation
By Anonymous on 02/29/2020
Application: Species: Human

p53-mediated apoptosis after treatment with NSC146109 for 12–16 hours

PMID: 29364875
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