NSC 146109 hydrochloride
Chemical Name: (10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride
Purity: ≥99%
Biological Activity
NSC 146109 hydrochloride is a cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Increases levels of endogenous p53 in tumor cells and protects p53 from Mdm2-mediated degradation. Displays some selectivity for tumor cells vs. normal cells in an MTT cell viability assay.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells.
Dolma et al.
Cancer Cell, 2003;3:285 -
Pilot screening programme for small molecule activators of p53.
Berkson et al.
Int.J.Cancer, 2005;115:701
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Citation for NSC 146109 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for NSC 146109 hydrochloride include:
1 Citation: Showing 1 - 1
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Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders.
Authors: Calo Et al.
Nature 2018;554:112
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p53-mediated apoptosis after treatment with NSC146109 for 12–16 hours
