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NTNCB hydrochloride

2155 Datasheet / COA / SDS
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2155/50
NTNCB hydrochloride | CAS No. 191931-56-3 | NPY Receptor Antagonists
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Description: Potent and selective non-peptidic NPY Y5 antagonist

Chemical Name: 2-Nitro-N-[[trans-4-[[[(1,2,3,4-tetrahydro-2-naphthalenyl)methyl]amino]methyl]cyclohexyl]methyl]benzenesulfonamide hydrochloride

Purity: ≥98%

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Biological Activity

NTNCB hydrochloride is a selective, non-peptide competitive NPY Y5 antagonist. Ki values are 8.0 and 16032 nM at human recombinant Y5 and Y1 receptors respectively. Potently antagonizes NPY inhibition of forskolin-stimulated cAMP. Displays some affinity for cloned human D2 and α2C receptors (Ki values are 63 and 100 nM respectively).

Technical Data

M.Wt:
508.07
Formula:
C25H33N3O4S.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
191931-56-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery of potent and selective small molecule NPY Y5 receptor antagonists.
    Islam et al.
    Bioorg.Med.Chem.Lett., 2002;12:1767

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VersaClone cDNA Plasmids

Human NPY5R (NP_006165) VersaClone cDNA

RDC0159

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