Potent, selective non-thiazolidinedione PPARγ
partial agonist (EC50
= 57 nM); produces ~25% maximum efficacy. Antagonizes full agonist activity by ~60% (IC50
~ 285 nM). Displays no activity at PPARα
receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPARγ
agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo
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All Tocris products are intended for laboratory research use only.
Distinct properties and advantages of a novel peroxisome proliferator-activated protein γ selective modulator.
Berger et al.