Chemical Name: L-Serine-O-phosphate
Biological ActivityGroup III metabotropic glutamate receptor agonist; analog of L-AP4 (Cat. No. 0103). Neuroprotective against excitotoxicity in cortical cell cultures. Inhibits proliferation and enhances neuronal differentiation in progenitor cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A chemical biology route to site-specific authentic protein modifications.
Yang et al.
Expanding the genetic code of Escherichia coli with phosphoserine.
Park et al.
A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation.
Saxe et al.
Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures.
Bruno et al.
[3H]-L-2-amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a.
Eriksen and Thomsen
Pharmacology of selective and non-selective metabotropic glutamate receptor agonists at L-AP4 receptors in ON bipolar cells.
Thoreson and Ulphani
Brain Res., 1995;676:93
Citations for O-Phospho-L-serine
The citations listed below are publications that use Tocris products. Selected citations for O-Phospho-L-serine include:
2 Citations: Showing 1 - 2
Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism.
Authors: Jiang Et al.
J Neurosci 2006;26:4318
Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP.
Authors: Mathiesen Et al.
Br J Pharmacol 2003;138:1026
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