O-Phospho-L-serine

Key Product Details

Product Description

O

-Phospho-L-serine is a group III metabotropic glutamate receptor agonist; analog of L-AP4 (Cat. No. 0103). Neuroprotective against excitotoxicity in cortical cell cultures. Inhibits proliferation and enhances neuronal differentiation in progenitor cells.

Product Specifications for O-Phospho-L-serine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for O-Phospho-L-serine

The following data is based on the product molecular weight 185.07.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.40 mL	27.02 mL	54.03 mL
5 mM	1.08 mL	5.40 mL	10.81 mL
10 mM	0.54 mL	2.70 mL	5.40 mL
50 mM	0.11 mL	0.54 mL	1.08 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Park Expanding the genetic code of Escherichia coli with phosphoserine. Science 2011 PMID: 21868676
• Yang A chemical biology route to site-specific authentic protein modifications. Science 2016 PMID: 27708052
• Saxe A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation. Chem.Biol. 2007 PMID: 17884634
• Thoreson and Ulphani Pharmacology of selective and non-selective metabotropic glutamate receptor agonists at L-AP4 receptors in ON bipolar cells. Brain Res. 1995 PMID: 7796182
• Eriksen and Thomsen [³H]-L-2-amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a. Br.J.Pharmacol. 1995 PMID: 8719808
• Bruno Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures. Eur.J.Pharmacol. 1996 PMID: 8880068

Product Documents for O-Phospho-L-serine