O-Phospho-L-serine (CAS 407-41-0): R&D Systems
Catalog Number: 0238
Alternate Names: L-SOP
Chemical Name: L-Serine-O-phosphate
Biological Activity
Group III metabotropic glutamate receptor agonist; analog of L-AP4 (Cat. No. 0103). Neuroprotective against excitotoxicity in cortical cell cultures. Inhibits proliferation and enhances neuronal differentiation in progenitor cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures.
    Bruno et al.
    Eur.J.Pharmacol., 1996;310:61
  2. [3H]-L-2-amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a.
    Eriksen and Thomsen
    Br.J.Pharmacol., 1995;116:3279
  3. Pharmacology of selective and non-selective metabotropic glutamate receptor agonists at L-AP4 receptors in ON bipolar cells.
    Thoreson and Ulphani
    Brain Res., 1995;676:93
  4. A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation.
    Saxe et al.
    Chem.Biol., 2007;14:1019
  5. A chemical biology route to site-specific authentic protein modifications.
    Yang et al.
    Science, 2016;354:623
  6. Expanding the genetic code of Escherichia coli with phosphoserine.
    Park et al.
    Science, 2011;333:1151

The citations listed below are publications that use Tocris products. Selected citations for O-Phospho-L-serine include:

1 Citations: Showing 1 - 1

  1. Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP.
    Authors: Mathiesen Et al.
    Br J Pharmacol 2003;138:1026

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