Selective group III metabotropic glutamate receptor agonist. Synaptic depressant. Agonist at the quisqualate-sensitized AP6 site in hippocampus.
Available as part of the Group III mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™. DL Mixture and D-isomer also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations.
Evans et al.
Antagonism of the synaptic depressant actions of L-AP4 in the lateral perforant path by MAP4.
Bushell et al.
Molecular diversity of glutamate receptors and implications for brain functions.
The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain.
Tones et al.
The citations listed below are publications that use Tocris products. Selected citations for L-AP4 include:
44 Citations: Showing 1 - 10 Filter your results:
Have you used L-AP4?
Submit a Review
Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.