Ocinaplon
Chemical Name: 2-Pyridinyl[7-(4-pyridinyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone
Purity: ≥98%
Biological Activity
Ocinaplon is a modulator of GABAA receptors. Displays modest selectivity for GABAA α1 receptors; displays partial agonist activity at α2-, α3- and α5-containing receptors. Exhibits anxiolytic activity.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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Selective anxiolysis produced by ocinaplon, a GABAA receptor modulator.
Lippa et al.
Proc.Natl.Acad.Sci.USA, 2005;102:7380 -
GABAA receptors as targets for novel anxiolytic drugs.
Rupprecht et al.
World J.Biol.Psychiatry, 2006;7:231 -
Comparative cue generalization profiles of L-838,417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, ZopiC., and various benzodiazepines in chlordiazep. and zol. drug discrimination.
Mirza et al.
J.Pharmacol.Exp.Ther., 2006;316:1291
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