Catalog Number: 4410
Chemical Name: 2-Pyridinyl[7-(4-pyridinyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone
Biological Activity
Modulator of GABAA receptors. Displays modest selectivity for GABAA α1 receptors; displays partial agonist activity at α2-, α3- and α5-containing receptors. Exhibits anxiolytic activity.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in 2eq.HCl and to 10 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Comparative cue generalization profiles of L-838,417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, zopiclone, and various benzodiazepines in chlordiazepoxide and zolpidem drug discrimination.
    Mirza et al.
    J.Pharmacol.Exp.Ther., 2006;316:1291
  2. Selective anxiolysis produced by ocinaplon, a GABAA receptor modulator.
    Lippa et al.
    Proc.Natl.Acad.Sci.USA, 2005;102:7380
  3. GABAA receptors as targets for novel anxiolytic drugs.
    Rupprecht et al.
    World J.Biol.Psychiatry, 2006;7:231
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