Chemical Name: 4'-((1R,2S)-2-aminocyclopropyl)biphenyl-3-ol
Biological ActivityPotent LSD1 inhibitor (IC50 = 20 nM). Exhibits some selectivity for LSD1 over MAO-B and MAO-A (IC50 values are 0.72 and 1.38 μM, respectively). Inhibits herpes simplex virus (HSV) immediate early gene expression and viral yield in vitro. Suppresses HSV primary infection in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency.
Liang et al.
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