Catalog Number: 3026
Alternate Names: Pranlukast
Chemical Name: N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4(4-phenylbutoxy)benzamide
Biological Activity
Selective cysteinyl leukotriene receptor 1 (CysLT1) antagonist (IC50 values are ~ 4 - 7 and 3620 nM for CysLT1 and CysLT2 respectively). Inhibits contraction of airway smooth muscle, microvascular leakage into airways and eosinophil infiltration. Can decrease symptoms of bronchial asthma.
Technical Data
  • M.Wt:
    481.5
  • Formula:
    C27H23N5O4
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    103177-37-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characterization of the human leukotriene CysLT1 receptor.
    Lynch et al.
    Nature, 1999;399:789
  2. Characterization of the human cysteinyl leukotriene 2 receptor.
    Heise et al.
    J.Biol.Chem., 2000;275:30531
  3. Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor antagonist (Pranlukast; ONO-1078).
    Suzuki et al.
    J.Asthma, 2003;40:395

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