Selective cysteinyl leukotriene receptor 1 (CysLT1
) antagonist (IC50
values are ~ 4 - 7 and 3620 nM for CysLT1
respectively). Inhibits contraction of airway smooth muscle, microvascular leakage into airways and eosinophil infiltration. Can decrease symptoms of bronchial asthma.
Soluble to 50 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Characterization of the human leukotriene CysLT1 receptor.
Lynch et al.
Characterization of the human cysteinyl leukotriene 2 receptor.
Heise et al.
Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor antagonist (Pranlukast; ONO-1078).
Suzuki et al.