Catalog Number: 2957
Chemical Name: 5-Chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl-1H-indole-2-carboxamide
Biological Activity
Potent CB1 receptor allosteric modulator (pEC50 = 8.24). Significantly increases binding of the CB1 agonist [3H]CP 55.940 (pKb = 5.67) and decreases binding of the CB1 inverse agonist [3H]SR 141716A (pKb = 5.95). Inhibits CB1 receptor antagonist efficacy in vitro (pKb = 7.57).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Allosteric modulation of the Cannabinoid CB1 receptor.
    Price et al.
    Mol.Pharmacol., 2005;68:1484
  2. Allosterism and the cannabinoid CB1 receptors: the shape of things to come.
    Trends Pharmacol.Sci., 2007;28:567

The citations listed below are publications that use Tocris products. Selected citations for Org 27569 include:

Showing Results 1 - 1 of 1

  1. CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity.
    Authors: Baillie Et al.
    Mol Pharmacol
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