Chemical Name: 5-Chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl-1H-indole-2-carboxamide
Biological ActivityOrg 27569 is a potent CB1 receptor allosteric modulator (pEC50 = 8.24). Significantly increases binding of the CB1 agonist [3H]CP 55.940 (pKb = 5.67) and decreases binding of the CB1 inverse agonist [3H]SR 141716A (pKb = 5.95). Inhibits CB1 receptor antagonist efficacy in vitro (pKb = 7.57).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Allosteric modulation of the Cannabinoid CB1 receptor.
Price et al.
Allosterism and the cannabinoid CB1 receptors: the shape of things to come.
Trends Pharmacol.Sci., 2007;28:567
Citations for Org 27569
The citations listed below are publications that use Tocris products. Selected citations for Org 27569 include:
2 Citations: Showing 1 - 2
CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity.
Authors: Baillie Et al.
Mol Pharmacol 2013;83:322
Real-time characterization of cannabinoid receptor 1 (CB1 ) allosteric modulators reveals novel mechanism of action.
Authors: Cawston Et al.
Br J Pharmacol 2013;170:893
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for Org 27569
Average Rating: 5 (Based on 1 Review)
Have you used Org 27569?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Allosteric modulation of radioactive Agonist (CP) and Antagonist (SR) binding by various concentrations of Org 27569 and inhibition of agonist stimulated GTPgS binding.