Org 27569

Tocris Bioscience | Catalog # 2957

Potent allosteric modulator of CB1 receptors
Tocris Bioscience
Discontinued Product
2957 has been discontinued. View all Cannabinoid R1/CB1 Modulators products.

Key Product Details

Description

Potent allosteric modulator of CB1 receptors
View all Cannabinoid R1/CB1 Modulators »

Product Description

Org 27569 is a potent CB1 receptor allosteric modulator (pEC50 = 8.24). Significantly increases binding of the CB1 agonist [3H]CP 55.940 (pKb = 5.67) and decreases binding of the CB1 inverse agonist [3H]SR 141716A (pKb = 5.95). Inhibits CB1 receptor antagonist efficacy in vitro (pKb = 7.57).

Product Specifications for Org 27569

Molecular Weight

409.95

Formula

C24H28ClN3O

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

5-Chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl-1H-indole-2-carboxamide

CAS Number

868273-06-7

PubChem ID

44828492

InChI Key

AHFZDNYNXFMRFQ-UHFFFAOYSA-N

SMILES

CCC2=C(C(NCCC3=CC=C(N4CCCCC4)C=C3)=O)NC1=CC=C(Cl)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.99 100

Preparing Stock Solutions for Org 27569

The following data is based on the product molecular weight 409.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.20 mL 24.39 mL
5 mM 0.49 mL 2.44 mL 4.88 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

Product Documents for Org 27569

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Org 27569

For research use only

Related Research Areas

Bioactive Lipids and Receptors

Customer Reviews for Org 27569 (1)

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  • Works as described, very interesting compound.
    Name: Jonathan Fay
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: COSH-1
    Verified Customer | Posted 05/30/2019
    For a constitutively inactive mutant tested, Org 27569 had enhanced potency and appeared to slow radio-labeled agonist dissociation so much that equilibrium was not achieved during the typical 1 hour incubation, at higher Org concentrations.
    Allosteric modulation of radioactive Agonist (CP) and Antagonist (SR) binding by various concentrations of Org 27569 and inhibition of agonist stimulated GTPgS binding.
    Org 27569 2957

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