Chemical Name: 5-Chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl-1H-indole-2-carboxamide
Biological ActivityPotent CB1 receptor allosteric modulator (pEC50 = 8.24). Significantly increases binding of the CB1 agonist [3H]CP 55.940 (pKb = 5.67) and decreases binding of the CB1 inverse agonist [3H]SR 141716A (pKb = 5.95). Inhibits CB1 receptor antagonist efficacy in vitro (pKb = 7.57).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Allosteric modulation of the Cannabinoid CB1 receptor.
Price et al.
Allosterism and the cannabinoid CB1 receptors: the shape of things to come.
Trends Pharmacol.Sci., 2007;28:567
Citations for Org 27569
The citations listed below are publications that use Tocris products. Selected citations for Org 27569 include:
2 Citations: Showing 1 - 2
CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity.
Authors: Baillie Et al.
Mol Pharmacol 2013;83:322
Real-time characterization of cannabinoid receptor 1 (CB1 ) allosteric modulators reveals novel mechanism of action.
Authors: Cawston Et al.
Br J Pharmacol 2013;170:893
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Allosteric modulation of radioactive Agonist (CP) and Antagonist (SR) binding by various concentrations of Org 27569 and inhibition of agonist stimulated GTPgS binding.