OSU 6162 hydrochloride
Chemical Name: (3S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride
Biological ActivityDopamine stabilizer; lacks high affinity for various neuroreceptors in vitro (Ki values are 447 and 1305 nM for D2 and D3 receptors respectively and > 1 μM for other targets). Exhibits high D2 receptor occupancy in vivo; highly active on dopamine synthesis and turnover. Induces stabilizing effects on psychomotor function in behavioral tests without inducing hypolocomotion or catalepsy.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
PNU-96391A (OSU6162) antagonizes the development of behavioural sensitization induced by DA agonists in a rat model for Parkinson's disease.
Nichols et al.
The DArgic stabilizers (-)-OSU6162 and ACR16 reverse (+)-MK-801-induced social withdrawal in rats.
Rung et al.
The DA stabilizers (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonyl-phenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low potentia
Natesan et al.
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