OSU 6162 hydrochloride

Key Product Details

Product Description

OSU 6162 hydrochloride is a dopamine stabilizer; lacks high affinity for various neuroreceptors in vitro (K_i values are 447 and 1305 nM for D₂ and D₃ receptors respectively and > 1 μM for other targets). Exhibits high D₂ receptor occupancy in vivo; highly active on dopamine synthesis and turnover. Induces stabilizing effects on psychomotor function in behavioral tests without inducing hypolocomotion or catalepsy.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for OSU 6162 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for OSU 6162 hydrochloride

The following data is based on the product molecular weight 317.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.15 mL	15.73 mL	31.46 mL
5 mM	0.63 mL	3.15 mL	6.29 mL
10 mM	0.31 mL	1.57 mL	3.15 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Natesan The DA stabilizers (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonyl-phenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low potentia J.Pharmacol.Exp.Ther. 2006 PMID: 16648369
• Rung The DArgic stabilizers (-)-OSU6162 and ACR16 reverse (+)-MK-801-induced social withdrawal in rats. Prog.Neuro-Psychopharm.Biol.Psychiat.
• Nichols PNU-96391A (OSU6162) antagonizes the development of behavioural sensitization induced by DA agonists in a rat model for Parkinson's disease. Neuropharmacology 2002 PMID: 12384167

Product Documents for OSU 6162 hydrochloride