OSU 6162 hydrochloride

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2599/10
2599/50
OSU 6162 hydrochloride | CAS No. 156907-84-5 | Additional Dopaminergic-related Products
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Description: Dopamine stabilizer
Alternative Names: PNU 96391

Chemical Name: (3S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride

Purity: ≥98%

Product Details
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Biological Activity

Dopamine stabilizer; lacks high affinity for various neuroreceptors in vitro (Ki values are 447 and 1305 nM for D2 and D3 receptors respectively and > 1 μM for other targets). Exhibits high D2 receptor occupancy in vivo; highly active on dopamine synthesis and turnover. Induces stabilizing effects on psychomotor function in behavioral tests without inducing hypolocomotion or catalepsy.

Technical Data

M.Wt:
317.87
Formula:
C15H23NO2S.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
156907-84-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. PNU-96391A (OSU6162) antagonizes the development of behavioural sensitization induced by DA agonists in a rat model for Parkinson's disease.
    Nichols et al.
    Neuropharmacology, 2002;43:817
  2. The DA stabilizers (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonyl-phenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low potentia
    Natesan et al.
    J.Pharmacol.Exp.Ther., 2006;318:810
  3. The DArgic stabilizers (-)-OSU6162 and ACR16 reverse (+)-MK-801-induced social withdrawal in rats.
    Rung et al.
    Prog.Neuro-Psychopharm.Biol.Psychiat., 2005;29:833

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