Potent and selective inhibitor of thromboxane (TXA2
) synthetase (IC50
= 4 nM). Does not inhibit prostacyclin (PGI2
) synthetase, cyclooxygenase or PGE2
> 1 mM). Inhibits platelet aggregation in vitro
and arachidonate-induced arterial contraction in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Pharmacological studies on the TXA2 synthetase inhibitor (E)-3-[p-(1H-imidazol-1ylmethyl)phenyl]-2-propenoic acid (OKY-046).
Hiraku et al.
Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets.
Naito et al.
Participation of thromboxane A2 in the cough response in guinea-pigs: antitussive effect of ozagrel.
Shinagawa et al.
The citations listed below are publications that use Tocris products. Selected citations for Ozagrel hydrochloride include:
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