Catalog Number: 1510
Alternate Names: OKY 046
Chemical Name: (2E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2-propenoic acid hydrochloride
Biological Activity
Potent and selective inhibitor of thromboxane (TXA2) synthetase (IC50 = 4 nM). Does not inhibit prostacyclin (PGI2) synthetase, cyclooxygenase or PGE2 isomerase (IC50 > 1 mM). Inhibits platelet aggregation in vitro and arachidonate-induced arterial contraction in vivo.
Technical Data
  • M.Wt:
    264.71
  • Formula:
    C13H12N2O2.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    74003-18-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological studies on the TXA2 synthetase inhibitor (E)-3-[p-(1H-imidazol-1ylmethyl)phenyl]-2-propenoic acid (OKY-046).
    Hiraku et al.
    Jpn.J.Pharmacol., 1986;41:393
  2. Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets.
    Naito et al.
    Eur.J.Pharmacol., 1983;91:41
  3. Participation of thromboxane A2 in the cough response in guinea-pigs: antitussive effect of ozagrel.
    Shinagawa et al.
    Br.J.Pharmacol., 2000;131:266
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ozagrel hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging.
    Authors: Wong Et al.
    Circ Res 2009;104:228
  2. Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum.
    Authors: Rancillac Et al.
    Proc Natl Acad Sci U S A 2006;26:6997

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