Recombinant Human p130Cas/BCAR1 His Protein

Novus Biologicals | Catalog # NBP2-51554

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Key Product Details

Source

E. coli

Tag

His

Applications

SDS-PAGE
View all p130Cas Proteins and Enzymes »

Product Specifications

Description

A denatured recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 465-848 of Human p130Cas/BCAR1

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSRLQQGVS ATVAHLLDLA GSAGATGSWR SPSEPQEPLV QDLQAAVAAV QSAVHELLEF ARSAVGNAAH TSDRALHAKL SRQLQKMEDV HQTLVAHGQA LDAGRGGSGA TLEDLDRLVA CSRAVPEDAK QLASFLHGNA SLLFRRTKAT APGPEGGGTL HPNPTDKTSS IQSRPLPSPP KFTSQDSPDG QYENSEGGWM EDYDYVHLQG KEEFEKTQKE LLEKGSITRQ GKSQLELQQL KQFERLEQEV SRPIDHDLAN WTPAQPLAPG RTGGLGPSDR QLLLFYLEQC EANLTTLTNA VDAFFTAVAT NQPPKIFVAH SKFVILSAHK LVFIGDTLSR QAKAADVRSQ VTHYSNLLCD LLRGIVATTK AAALQYPSPS AAQDMVE

Purity

>85%, by SDS-PAGE

Predicted Molecular Mass

43.9 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Application Notes

Denatured protein is most likely not the best option for functional studies. It is better suited for Western Blot (WB) or imaging assays.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human p130Cas/BCAR1 His Protein

SDS-PAGE: Recombinant Human p130Cas/BCAR1 His Protein [NBP2-51554]

SDS-PAGE: Recombinant Human p130Cas/BCAR1 His Protein [NBP2-51554]

SDS-Page: p130Cas/BCAR1 Recombinant Protein [NBP2-51554] - 15% SDS Page (3 ug)
SDS-PAGE: Recombinant Human p130Cas/BCAR1 His Protein [NBP2-51554]

SDS-PAGE: Recombinant Human p130Cas/BCAR1 His Protein [NBP2-51554]

SDS-Page: p130Cas/BCAR1 Recombinant Protein [NBP2-51554] - 15% SDS Page (3 ug)

Formulation, Preparation, and Storage

NBP2-51554
Formulation 20 mM Tris-HCl buffer (pH 8.0), 0.4M UREA, 10% glycerol
Preservative No Preservative
Concentration 0.5 mg/ml
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: p130Cas

BCAR1/p130CAS functions as a scaffolding protein for components of various kinase signaling pathways. It is involved in integrin signaling for cell motility as well as netrin signaling for the guidance of commissural axons. Overexpression of BCAR1/p130CAS has been shown to confer antiestrogen resistance in breast cancer cells. Alternate names for BCAR1/p130CAS include breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, CAS scaffolding protein family member 1, CAS, and CRKAS.

Long Name

Breast Cancer Anti-estrogen Resistance 1

Alternate Names

BCAR1, CASS1, CRKAS

Gene Symbol

BCAR1

Additional p130Cas Products

Product Documents for Recombinant Human p130Cas/BCAR1 His Protein

Certificate of Analysis

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Product Specific Notices for Recombinant Human p130Cas/BCAR1 His Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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