NAMPT activator. Proneurogenic and neuroprotective. Protects newborn neurons in the dentate gyrus by mitigating cell death. Also enhances learning and memory in aged rats. Orally available and brain penetrant. Also revents doxorubicin-mediated toxicity in osteosarcoma cells and restores intracellular NAD levels.
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All Tocris products are intended for laboratory research use only.
Discovery of a proneurogenic, neuroprotective chemical.
Pieper et al.
P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage.
Wang et al.