Catalog Number: 4076
Chemical Name: 3,6-Dibromo-α-[(phenylamino)methyl]-9H-carbazole-9-ethanol
Biological Activity
NAMPT activator. Proneurogenic and neuroprotective. Protects newborn neurons in the dentate gyrus by mitigating cell death. Also enhances learning and memory in aged rats. Orally available and brain penetrant. Also revents doxorubicin-mediated toxicity in osteosarcoma cells and restores intracellular NAD levels.
Technical Data
  • M.Wt:
    474.19
  • Formula:
    C21H18Br2N2O
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    301353-96-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of a proneurogenic, neuroprotective chemical.
    Pieper et al.
    Cell, 2010;142:39
  2. P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage.
    Wang et al.
    Cell, 2014;158:1324

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