PAOPA
Chemical Name: (3R)-2-Oxo-3-[[(2S)-2-Pyrrolidinylcarbonyl]amino]-1-pyrrolidineacetamide
Purity: ≥98%
Biological Activity
PAOPA is an allosteric modulator of dopamine D2 receptors. Prevents and reverses behavioral and biochemical abnormalities in an amphetamine-sensitized animal model of schizophrenia.Technical Data
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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PAOPA, a potent DA D2 receptor allosteric modulator, prevents and reverses behavioral and biochemical abnormalities in an amphetamine-sensitized preclinical animal model of schizophrenia.
Beyaert et al.
Eur.Neuropsychopharmacol., 2013;23:253 -
Preclinical pharmacokinetic and toxicological evaluation of MIF-1 peptidomimetic, PAOPA: examining the pharmacology of a selective DA D2 receptor allosteric modulator for the treatment of schizophrenia.
Tan et al.
Peptides, 2011;42:89 -
PAOPA, a potent analogue of Pro-Leu-glycinamide and allosteric modulator of the DA D2 receptor, prevents NMDA receptor antagonist (MK-801)-induced deficits in social interaction in the rat: implications for the treatment of negative symptoms in schizophre
Dyck et al.
Schizophr.Res., 2011;125:89
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