PAOPA

Key Product Details

Product Description

PAOPA is an allosteric modulator of dopamine D₂ receptors. Prevents and reverses behavioral and biochemical abnormalities in an amphetamine-sensitized animal model of schizophrenia.

Product Specifications for PAOPA

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PAOPA

The following data is based on the product molecular weight 254.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.93 mL	19.66 mL	39.33 mL
5 mM	0.79 mL	3.93 mL	7.87 mL
10 mM	0.39 mL	1.97 mL	3.93 mL
50 mM	0.08 mL	0.39 mL	0.79 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Tan Preclinical pharmacokinetic and toxicological evaluation of MIF-1 peptidomimetic, PAOPA: examining the pharmacology of a selective DA D2 receptor allosteric modulator for the treatment of schizophrenia. Peptides 2011 PMID: 23416534
• Dyck PAOPA, a potent analogue of Pro-Leu-glycinamide and allosteric modulator of the DA D2 receptor, prevents NMDA receptor antagonist (MK-801)-induced deficits in social interaction in the rat: implications for the treatment of negative symptoms in schizophre Schizophr.Res. 2011 PMID: 21036015
• Beyaert PAOPA, a potent DA D2 receptor allosteric modulator, prevents and reverses behavioral and biochemical abnormalities in an amphetamine-sensitized preclinical animal model of schizophrenia. Eur.Neuropsychopharmacol. 2013 PMID: 22658400

Product Documents for PAOPA