High affinity σ2
receptor agonist (Ki
values are 0.8 and 15.2 nM for σ2
receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea pig bladder and ileum (EC50
values are 2.62 and 3.96 μ
M respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.
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All Tocris products are intended for laboratory research use only.
New σ and 5-HT1A receptor ligands: ω-(tetralin-1-yl)-n-alkylamine derivatives.
Berardi et al.
A new method for evaluating σ2 ligand activity in the isolated guinea-pig bladder.
Colabufo et al.