PB 28 dihydrochloride
Chemical Name: 1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine dihydrochloride
Biological ActivityHigh affinity σ2 receptor agonist (Ki values are 0.8 and 15.2 nM for σ2 and σ1 receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea pig bladder and ileum (EC50 values are 2.62 and 3.96 μM respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
New σ and 5-HT1A receptor ligands: ω-(tetralin-1-yl)-n-alkylamine derivatives.
Berardi et al.
A new method for evaluating σ2 ligand activity in the isolated guinea-pig bladder.
Colabufo et al.
Antiproliferative and cytotoxic effects of some σ2 agonists and σ1 antagonists in tumour cell lines.
Colabufo et al.
Citation for PB 28 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for PB 28 dihydrochloride include:
1 Citation: Showing 1 - 1
σ1 receptor ligands control a switch between passive and active threat responses.
Authors: Rennekamp Et al.
Nat Chem Biol 2016;12:552
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Cell viability MTT assay. Sigma-2 receptor ligand PB28 at low concentration (1-10uM) promotes cellular viability in the presence of toxin paraquat, while high concentration (100uM) kills cells.