PB 28 dihydrochloride

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2562/10
2562/50
PB 28 dihydrochloride | CAS No. 172907-03-8 | Sigma2 Receptor Agonists
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Description: High affinity σ2 agonist

Chemical Name: 1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine dihydrochloride

Purity: ≥99%

Product Details
Citations (1)
Reviews (1)

Biological Activity

High affinity σ2 receptor agonist (Ki values are 0.8 and 15.2 nM for σ2 and σ1 receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea pig bladder and ileum (EC50 values are 2.62 and 3.96 μM respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.

Technical Data

M.Wt:
443.5
Formula:
C24H38N2O.2HCl
Solubility:
Soluble to 20 mM in water with gentle warming
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
172907-03-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. New σ and 5-HT1A receptor ligands: ω-(tetralin-1-yl)-n-alkylamine derivatives.
    Berardi et al.
    J.Med.Chem., 1996;39:176
  2. A new method for evaluating σ2 ligand activity in the isolated guinea-pig bladder.
    Colabufo et al.
    Naunyn-Schmied.Arch.Pharmacol., 2003;368:106
  3. Antiproliferative and cytotoxic effects of some σ2 agonists and σ1 antagonists in tumour cell lines.
    Colabufo et al.
    Naunyn-Schmied.Arch.Pharmacol., 2004;370:106

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Citation for PB 28 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for PB 28 dihydrochloride include:

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Dual effect of Sigma-2 receptor ligand PB28 on viability of 661W cells.
By Timur Mavlyutov on 02/04/2018
Species: Mouse

Cell viability MTT assay. Sigma-2 receptor ligand PB28 at low concentration (1-10uM) promotes cellular viability in the presence of toxin paraquat, while high concentration (100uM) kills cells.


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