PB 28 dihydrochloride

Tocris Bioscience | Catalog # 2562

High affinity σ2 agonist
Tocris Bioscience

Key Product Details

Description

High affinity σ2 agonist
View all Sigma2 Receptor Agonists »

Product Description

PB 28 dihydrochloride is a high affinity σ2 receptor agonist (Ki values are 0.8 and 15.2 nM for σ2 and σ1 receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea pig bladder and ileum (EC50 values are 2.62 and 3.96 μM respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.

Product Specifications for PB 28 dihydrochloride

Molecular Weight

443.50

Formula

C24H38N2O.2HCl

Storage

Desiccate at +4°C

Purity

≥99% (HPLC)

Chemical Name

1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine dihydrochloride

CAS Number

172907-03-8

PubChem ID

46861545

InChI Key

DSRBJOQIBXACIV-UHFFFAOYSA-N

SMILES

COC1=CC=CC2=C1CCCC2CCCN3CCN(C4CCCCC4)CC3.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 8.87 20 with gentle warming

Preparing Stock Solutions for PB 28 dihydrochloride

The following data is based on the product molecular weight 443.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.27 mL 56.37 mL 112.74 mL
1 mM 2.25 mL 11.27 mL 22.55 mL
2 mM 1.13 mL 5.64 mL 11.27 mL
10 mM 0.23 mL 1.13 mL 2.25 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Product Documents for PB 28 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PB 28 dihydrochloride

For research use only

Citations for PB 28 dihydrochloride

Customer Reviews for PB 28 dihydrochloride (1)

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  • Dual effect of Sigma-2 receptor ligand PB28 on viability of 661W cells.
    Name: Timur Mavlyutov
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: 661W
    Verified Customer | Posted 02/04/2018
    Cell viability MTT assay. Sigma-2 receptor ligand PB28 at low concentration (1-10uM) promotes cellular viability in the presence of toxin paraquat, while high concentration (100uM) kills cells.
    PB 28 dihydrochloride 2562

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