Catalog Number: 2562
Chemical Name: 1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine dihydrochloride
Biological Activity
High affinity σ2 receptor agonist (Ki values are 0.8 and 15.2 nM for σ2 and σ1 receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea pig bladder and ileum (EC50 values are 2.62 and 3.96 μM respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.
Technical Data
  • M.Wt:
    443.5
  • Formula:
    C24H38N2O.2HCl
  • Solubility:
    Soluble to 20 mM in water with gentle warming
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    172907-03-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. New σ and 5-HT1A receptor ligands: ω-(tetralin-1-yl)-n-alkylamine derivatives.
    Berardi et al.
    J.Med.Chem., 1996;39:176
  2. A new method for evaluating σ2 ligand activity in the isolated guinea-pig bladder.
    Colabufo et al.
    Naunyn-Schmied.Arch.Pharmacol., 2003;368:106

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