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PBIT

Catalog #: 5930 Datasheet / COA / SDS

Discontinued Product

5930 has been discontinued.
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PBIT | CAS No. 2514-30-9 | Histone Demethylase Inhibitors
1 Image
Description: JARID1 (Jumonji AT-Rich Interactive Domain 1) inhibitor

Chemical Name: 2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one

Purity: ≥98%

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Biological Activity

PBIT is a JARID1 (Jumonji AT-Rich Interactive Domain 1) inhibitor (IC50 values are 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively). Selective for JARID1 over UTX and JMJD3. Increases levels of methylated H3K4 in JARIDB1-transfected HeLa cells and MCF7 cells. Inhibits proliferation of breast cancer cell lines expressing high levels of JARIDB1.

Technical Data

M.Wt:
241.31
Formula:
C14H11NOS
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
2514-30-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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