PD 161570

Catalog # Availability Size / Price Qty
3724/10
3724/50
Cat.No. 3724 - PD 161570 | C26H35Cl2N7O | CAS No. 192705-80-9
1 Image
Description: Selective FGFR inhibitor

Chemical Name: N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea

Purity: ≥98%

Product Details
Citations (2)
Supplemental Products
Reviews

Biological Activity

Selective FGFR inhibitor (IC50 values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). Inhibits FGFR receptor phosphorylation (IC50 = 622 nM) and growth of A121 cells in vitro.

Technical Data

M.Wt:
532.51
Formula:
C26H35Cl2N7O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
192705-80-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors.
    Hamby et al.
    J.Med.Chem., 1997;40:2296
  2. Inhibition of FGF-1 receptor tyrosine kinase activity by PD 161570, a new protein-tyrosine kinase inhibitor.
    Batley et al.
    Life Sci., 1998;62:143
  3. Thyroid hormone activates fibroblast growth factor receptor-1 in bone.
    Stevens et al.
    Mol.Endocrinology, 2003;17:1751

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for PD 161570

The citations listed below are publications that use Tocris products. Selected citations for PD 161570 include:

2 Citations: Showing 1 - 2

  1. Paracrine effects of embryo-derived FGF4 and BMP4 during pig trophoblast elongation.
    Authors: Magaña Et al.
    Dev Biol  2014;387:15
  2. Modulation of pluripotency in the porcine embryo and iPS cells.
    Authors: Rodríguez Et al.
    J Exp Bot  2012;7:e49079

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for PD 161570

There are currently no reviews for this product. Be the first to review PD 161570 and earn rewards!

Have you used PD 161570?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.