Selective FGFR inhibitor (IC50
values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). Inhibits FGFR receptor phosphorylation (IC50
= 622 nM) and growth of A121 cells in vitro
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold for research purposes under agreement from Pfizer Inc.
Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors.
Hamby et al.
Inhibition of FGF-1 receptor tyrosine kinase activity by PD 161570, a new protein-tyrosine kinase inhibitor.
Batley et al.
Life Sci., 1998;62:143
Thyroid hormone activates fibroblast growth factor receptor-1 in bone.
Stevens et al.
The citations listed below are publications that use Tocris products. Selected citations for PD 161570 include:
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