Catalog Number: 3724
Chemical Name: N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
Biological Activity
Selective FGFR inhibitor (IC50 values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). Inhibits FGFR receptor phosphorylation (IC50 = 622 nM) and growth of A121 cells in vitro.
Technical Data
  • M.Wt:
    532.51
  • Formula:
    C26H35Cl2N7O
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    192705-80-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors.
    Hamby et al.
    J.Med.Chem., 1997;40:2296
  2. Inhibition of FGF-1 receptor tyrosine kinase activity by PD 161570, a new protein-tyrosine kinase inhibitor.
    Batley et al.
    Life Sci., 1998;62:143
  3. Thyroid hormone activates fibroblast growth factor receptor-1 in bone.
    Stevens et al.
    Mol.Endocrinology, 2003;17:1751
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PD 161570 include:

1 Citations: Showing 1 - 1

  1. Modulation of pluripotency in the porcine embryo and iPS cells.
    Authors: Rodríguez Et al.
    J Exp Bot 2012;7:e49079

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