Chemical Name: N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
Biological ActivityPD 161570 is a selective FGFR inhibitor (IC50 values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). Inhibits FGFR receptor phosphorylation (IC50 = 622 nM) and growth of A121 cells in vitro.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors.
Hamby et al.
Inhibition of FGF-1 receptor tyrosine kinase activity by PD 161570, a new protein-tyrosine kinase inhibitor.
Batley et al.
Life Sci., 1998;62:143
Citations for PD 161570
The citations listed below are publications that use Tocris products. Selected citations for PD 161570 include:
2 Citations: Showing 1 - 2
Paracrine effects of embryo-derived FGF4 and BMP4 during pig trophoblast elongation.
Authors: Magaña Et al.
Dev Biol 2014;387:15
Modulation of pluripotency in the porcine embryo and iPS cells.
Authors: Rodríguez Et al.
J Exp Bot 2012;7:e49079
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