PD 161570

Key Product Details

Product Description

PD 161570 is a selective FGFR inhibitor (IC₅₀ values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). Inhibits FGFR receptor phosphorylation (IC₅₀ = 622 nM) and growth of A121 cells in vitro.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PD 161570

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PD 161570

The following data is based on the product molecular weight 532.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.88 mL	9.39 mL	18.78 mL
5 mM	0.38 mL	1.88 mL	3.76 mL
10 mM	0.19 mL	0.94 mL	1.88 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

• Batley Inhibition of FGF-1 receptor tyrosine kinase activity by PD 161570, a new protein-tyrosine kinase inhibitor. Life Sci. 1998 PMID: 9488112
• Stevens Thyroid hormone activates fibroblast growth factor receptor-1 in bone. Mol.Endocrinology 2003 PMID: 12805413
• Hamby Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors. J.Med.Chem. 1997 PMID: 9240345

Product Documents for PD 161570