Potent and selective inhibitor of CYP3A4 (IC50
values are 0.03, 17 and 70 μ
M for CYP3A4, CYP3A5 and CYP3A7 respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold for research purposes under agreement from Pfizer Inc.
Selective mechanism-based inactivation of cytochrome P4503A4 by cyp3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of cytochrome P4503A4 versus P4503A5 in the metabolism of drugs.
Walsky et al.
Am.Soc.Pharmacol.Exp.Ther., 2012;:Epub ahead of print