PF 4981517

Key Product Details

Product Description

PF 4981517 is a potent and selective inhibitor of CYP3A4 (IC₅₀ values are 0.03, 17 and 70 μM for CYP3A4, CYP3A5 and CYP3A7 respectively).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PF 4981517

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PF 4981517

The following data is based on the product molecular weight 456.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.19 mL	10.95 mL	21.90 mL
5 mM	0.44 mL	2.19 mL	4.38 mL
10 mM	0.22 mL	1.10 mL	2.19 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Walsky Selective mechanism-based inactivation of cytochrome P4503A4 by cyp3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of cytochrome P4503A4 versus P4503A5 in the metabolism of drugs. Am.Soc.Pharmacol.Exp.Ther.

Product Documents for PF 4981517