PF 4981517

Catalog # Availability Size / Price Qty
4252/10
4252/50
PF 4981517 | CAS No. 1390637-82-7 | Cytochrome P450 Inhibitors
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Description: Selective CYP3A4 inhibitor

Chemical Name: (1-Methyl-3-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-4-[(3S)-3-piperidin-1-ylpyrrolidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine)

Purity: ≥98%

Product Details
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Biological Activity

Potent and selective inhibitor of CYP3A4 (IC50 values are 0.03, 17 and 70 μM for CYP3A4, CYP3A5 and CYP3A7 respectively).

Technical Data

M.Wt:
456.59
Formula:
C26H32N8
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1390637-82-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Selective mechanism-based inactivation of cytochrome P4503A4 by cyp3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of cytochrome P4503A4 versus P4503A5 in the metabolism of drugs.
    Walsky et al.
    Am.Soc.Pharmacol.Exp.Ther., 2012;:Epub ahead of print

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