PF 915275

Catalog # Availability Size / Price Qty
3291/10
3291/50
PF 915275 | CAS No. 857290-04-1 | a11 beta-HSD Inhibitors
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Description: Potent and selective 11β-hydroxysteroid dehydrogenase inhibitor

Chemical Name: N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide

Purity: ≥98%

Product Details
Citations (3)
Reviews

Biological Activity

Potent and selective 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) inhibitor (Ki = 2.3 nM) that displays little activity at 11βHSD2 (1.5% inhibition at 10 μM). Inhibits the conversion of prednisone to prednisolone in human hepatocytes in vitro (EC50 = 15 nM) and has antidiabetic activity in vivo. Orally active.

Technical Data

M.Wt:
350.39
Formula:
C18H14N4O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
857290-04-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for PF 915275

The citations listed below are publications that use Tocris products. Selected citations for PF 915275 include:

3 Citations: Showing 1 - 3

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