Chemical Name: (3aS,8aR)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol 5-(N-phenylcarbamate)
Biological ActivityPhysostigmine analog that inhibits acetylcholinesterase. Inhibits production of amyloid precursor protein (APP) and Aβ. Improves morris water maze performance of scopolamine-treated rats.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The cholinesterase inhibitor, phenserine, improves morris water maze performance of scopolamine-treated rats.
Janas et al.
Life Sci., 2005;76:1073
Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-β peptide.
Utsuki et al.
Expert Opin.Investig.Drugs, 2007;16:1087
Citation for Phenserine
The citations listed below are publications that use Tocris products. Selected citations for Phenserine include:
1 Citation: Showing 1 - 1
Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells.
Authors: Elgueta Et al.
Sci Rep 2015;9:6
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