Catalog Number: 1791
Alternate Names: Protein kinase C zeta pseudosubstrate
Biological Activity
Inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amino acids 113 - 129 of PKC ζ pseudosubstrate domain linked by a disulphide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide. Induces mast cell degranulation by a PKC ζ-independent pathway.
Technical Data
  • M.Wt:
    4673.59
  • Formula:
    C208H336N74O44S3
  • Sequence:
    CRQIKIWFQNRRMKWKK CSIYRRGARRWRKLYRAN*

    (Modifications: Disulfide bridge between 1 -1*)

  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Evidence of ζ protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis.
    Laudanna et al.
    J.Biol.Chem, 1998;273:30306
  2. A myristoylated pseudosubstrate peptide of PKC-ζ induces degranulation in HMC-1 cells independently of PKC-ζ activity.
    Lim et al.
    Life Sci., 2008;82:733
  3. Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse.
    Theodore et al.
    J.Neurosci., 1995;15:7158
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PKC ζ pseudosubstrate include:

1 Citations: Showing 1 - 1

  1. TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer.
    Authors: Mu Et al.
    Nat Commun 2011;2:330

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