PKC ζ pseudosubstrate
Biological ActivityPKC ζ pseudosubstrate is an inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amino acids 113 - 129 of PKC ζ pseudosubstrate domain linked by a disulphide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide. Induces mast cell degranulation by a PKC ζ-independent pathway.
(Modifications: Disulfide bridge between 1 -1*)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A myristoylated pseudosubstrate peptide of PKC-ζ induces degranulation in HMC-1 cells independently of PKC-ζ activity.
Lim et al.
Life Sci., 2008;82:733
Evidence of ζ protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis.
Laudanna et al.
Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse.
Theodore et al.
Citations for PKC ζ pseudosubstrate
The citations listed below are publications that use Tocris products. Selected citations for PKC ζ pseudosubstrate include:
2 Citations: Showing 1 - 2
Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice.
Authors: Mattson Et al.
J Biol Chem 2019;
TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer.
Authors: Mu Et al.
Nat Commun 2011;2:330
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