Chemical Name: 7-(1,1-Dimethylheptyl)-9-methoxy-4,4-dimethyl-4H-benzopyrano[3,4-d]isoxazole
Biological ActivityPotent and selective CB2 receptor agonist (Ki = 12.8 nM; EC50 = 38.67 nM). Exhibits negligible affinity for the CB1 receptor (Ki > 40,000 nM) and no activity at the GPR55. Suppresses neuroinflammation by reducing microglial activation in a multiple sclerosis mouse model. BBB permeable; anti-inflammatory and neuroprotective.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Targeting cannabinoid CB2 receptors in the central nervous system. Medicinal chemistry approaches with focus on neurodegenerative disorders.
Navarro et al.
Front. Neurosci., 2016;10:406
Chromenopyrazole, a versatile cannabinoid scaffold with in vivo activity in a model of multiple sclerosis.
Morales et al.
Biological characterization of PM226, a chromenoisoxazole, as a selective CB2 receptor agonist with neuroprotective profile.
Gómez-Cañas et al.
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