Non-pungent vanilloid TRPV1 (VR1) receptor agonist (Ki
= 3.1 μ
M) that displays non-cooperative binding. Induces apoptosis via a non-VR1 mechanism in Jurkat cells and causes vasoconstriction in vivo
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Phorboid 20-homovanillates induce apoptosis through a VR1-independent mechanism.
Macho et al.
Functional and desensitizing effects of the novel synthetic vanilloid-like agent 12-phenylacetate 13-acetate 20-homovanillate (PPAHV) in the perfused rat hindlimb.
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A novel agonist, phorbol 12-phenylacetate 13-acetate 20-homovanillate, abolishes positive cooperativity of binding by the vanilloid receptor.
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