Proxyfan oxalate

Key Product Details

Product Description

Proxyfan oxalate is a high affinity histamine H₃ receptor ligand (pK_i = 8.62) that acts as a protean agonist at recombinant and native receptors. In functional studies, activity ranges from full agonist to inverse agonist depending on system used. Displays partial agonist effects on cAMP inhibition and MAPK activity, neutral antagonist activity on histamine release and partial inverse agonism of [³H]-arachidonic acid release.

Product Specifications for Proxyfan oxalate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Proxyfan oxalate

The following data is based on the product molecular weight 306.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.26 mL	16.32 mL	32.65 mL
5 mM	0.65 mL	3.26 mL	6.53 mL
10 mM	0.33 mL	1.63 mL	3.26 mL
50 mM	0.07 mL	0.33 mL	0.65 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Krueger G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations. J.Pharmacol.Exp.Ther 2005 PMID: 15821027
• Gbahou Protean agonism at histamine H₃ receptors in vitro and in vivo. Proc.Natl.Acad.Sci.USA
• Baldi The H₃ receptor protean agonist proxyfan enhances the expression of fear memory in the rat. Neuropharmacology 2005 PMID: 15695163

Product Documents for Proxyfan oxalate