Proxyfan oxalate

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2477/10
2477/50
Proxyfan oxalate | CAS No. 1620017-81-3 | Histamine H3 Receptor Agonists
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Description: High affinity H3 ligand

Chemical Name: 4-[3-(Phenylmethoxy)propyl]-1H-imidazole oxalate

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

High affinity histamine H3 receptor ligand (pKi = 8.62) that acts as a protean agonist at recombinant and native receptors. In functional studies, activity ranges from full agonist to inverse agonist depending on system used. Displays partial agonist effects on cAMP inhibition and MAPK activity, neutral antagonist activity on histamine release and partial inverse agonism of [3H]-arachidonic acid release.

Technical Data

M.Wt:
306.32
Formula:
C13H16N2O.C2H2O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in water
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1620017-81-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The H3 receptor protean agonist proxyfan enhances the expression of fear memory in the rat.
    Baldi et al.
    Neuropharmacology, 2005;48:246
  2. G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations.
    Krueger et al.
    J.Pharmacol.Exp.Ther, 2005;314:271
  3. Protean agonism at histamine H3 receptors in vitro and in vivo.
    Gbahou et al.
    Proc.Natl.Acad.Sci.USA, 2003;100:11086

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Citation for Proxyfan oxalate

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