Catalog Number: 2477
Chemical Name: 4-[3-(Phenylmethoxy)propyl]-1H-imidazole oxalate
Biological Activity
High affinity histamine H3 receptor ligand (pKi = 8.62) that acts as a protean agonist at recombinant and native receptors. In functional studies, activity ranges from full agonist to inverse agonist depending on system used. Displays partial agonist effects on cAMP inhibition and MAPK activity, neutral antagonist activity on histamine release and partial inverse agonism of [3H]-arachidonic acid release.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in water
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The H3 receptor protean agonist proxyfan enhances the expression of fear memory in the rat.
    Baldi et al.
    Neuropharmacology, 2005;48:246
  2. G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations.
    Krueger et al.
    J.Pharmacol.Exp.Ther, 2005;314:271
  3. Protean agonism at histamine H3 receptors in vitro and in vivo.
    Gbahou et al.
    Proc.Natl.Acad.Sci.USA, 2003;100:11086

The citations listed below are publications that use Tocris products. Selected citations for Proxyfan oxalate include:

Showing Results 1 - 1 of 1

  1. Development of time-resolved fluorescent based [EU]-GTP binding assay for selection of human Histamine 3 receptor antagonists/inverse agonist: a potential target for Alzheimer's treatment.
    Authors: Singh Et al.
    Ann Neurosci
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