PSB 10 hydrochloride

Catalog # Availability Size / Price Qty
2010/10
2010/50
PSB 10 hydrochloride | CAS No. 591771-91-4 | Adenosine A3 Receptor Antagonists
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Description: Potent, highly selective hA3 receptor antagonist/inverse agonist

Chemical Name: 8-Ethyl-1,4,7,8-tetrahydro-4-methyl-2-(2,3,5-trichlorophenyl)-5H-imidazo[2,1-i]purin-5-one monohydrochloride

Purity: ≥98%

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Biological Activity

Potent and highly selective antagonist for the human adenosine A3 receptor, with low affinity for the rat A3 receptor (Ki values are 0.44 and > 17000 nM respectively). Displays > 3800-fold selectivity over human A1, A2A and A2B receptors (Ki values are 4.1, 3.3 and 30 μM respectively) and > 1800-fold selectivity over rat A1 and A2A receptors. Acts as an inverse agonist in the [35S]GTPγS binding assay in hA3-CHO cells (IC50 = 4 nM). Produces thermal hyperalgesia in mice in vivo.

Technical Data

M.Wt:
435.14
Formula:
C16H14Cl3N5O.HCl
Solubility:
Soluble to 25 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
591771-91-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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