Chemical Name: 1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide
Biological ActivityReversible, non-competitive inhibitor of threonine dehydrogenase (TDH) (IC50 ~500 nM). Induces autophagy and inhibits cell proliferation in mouse embryonic stem (ES) cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Targeted killing of a mammalian cell based upon its specialized metabolic state.
Alexander et al.
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