Qc 1

Catalog # Availability Size / Price Qty
5055/10
5055/50
Cat.No. 5055 - Qc 1 | C23H16F3N3O2S | CAS No. 403718-45-6
1 Image
Description: Threonine dehydrogenase inhibitor

Chemical Name: 1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide

Product Details
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Biological Activity

Reversible, non-competitive inhibitor of threonine dehydrogenase (TDH) (IC50 ~500 nM). Induces autophagy and inhibits cell proliferation in mouse embryonic stem (ES) cells.

Technical Data

Formula:
C23H16F3N3O2S
Solubility:
Soluble to 50 mM in DMSO
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
403718-45-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Targeted killing of a mammalian cell based upon its specialized metabolic state.
    Alexander et al.
    Proc.Natl.Acad.Sci.USA, 2011;108:15828

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