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Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)
Succinate dehydrogenase inhibitor
Inosine monophosphatase dehydrogenase (IMPDH) inhibitor
GAPDH inhibitor; neuroprotective
Inosine monophosphate dehydrogenase (IMPDH) inhibitor
Threonine dehydrogenase inhibitor
Inosine monophosphatase dehydrogenase (IMPDH) inhibitor
High affinity 15-PGDH inhibitor; promotes hematopoiesis and hepatocyte proliferation
Phosphoglycerate dehydrogenase (PHGDH) inhibitor
Potent 17β-hydroxysteroid dehydrogenase type 5 inhibitor;orally bioavailable
Malate dehydrogenase-2 (MDH2) inhibitor; also inhibits HIF-1α
Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)
Potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1)