Dehydrogenase Inhibitors: Products

Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)

Succinate dehydrogenase inhibitor

Inosine monophosphatase dehydrogenase (IMPDH) inhibitor

GAPDH inhibitor; neuroprotective

Inosine monophosphate dehydrogenase (IMPDH) inhibitor

Threonine dehydrogenase inhibitor

PDH and KGDH inhibitor

Inosine monophosphatase dehydrogenase (IMPDH) inhibitor

High affinity 15-PGDH inhibitor; promotes hematopoiesis and hepatocyte proliferation

Phosphoglycerate dehydrogenase (PHGDH) inhibitor

Potent 17β-hydroxysteroid dehydrogenase type 5 inhibitor;orally bioavailable

Malate dehydrogenase-2 (MDH2) inhibitor; also inhibits HIF-1α

Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)

Potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1)