QX 314 bromide

Catalog # Availability Size / Price Qty
1014/100
QX 314 bromide | CAS No. 24003-58-5 | Voltage-gated Sodium Channel Blockers
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Description: Na+ channel blocker

Chemical Name: N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide

Purity: ≥99%

Product Details
Citations (31)
Reviews (1)

Biological Activity

Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels. Intracellular QX 314 bromide also inhibits calcium currents in hippocampal CA1 pyramidal neurons.

Technical Data

M.Wt:
343.31
Formula:
C16H27N2OBr
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
24003-58-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for QX 314 bromide

The citations listed below are publications that use Tocris products. Selected citations for QX 314 bromide include:

31 Citations: Showing 1 - 10

  1. TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala.
    Authors: Li Et al.
    Elife  2019;8
  2. KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice.
    Authors: Spoljaric Et al.
    Cell Rep  2019;26:1073
  3. AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP.
    Authors: Purkey Et al.
    Cell Rep  2018;25:974
  4. Dendrite-Specific Amplification of Weak Synaptic Input during Network Activity In Vivo.
    Authors: Ferrarese Et al.
    Cell Rep  2018;24:3455
  5. Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain.
    Authors: Acuña Et al.
    J Clin Invest  2016;126:2547
  6. Enhanced GABAA-Mediated Tonic Inhibition in Auditory Thalamus of Rats with Behavioral Evidence of Tinnitus.
    Authors: Sametsky Et al.
    J Neurosci  2015;35:9369
  7. Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.
    Authors: Puranam Et al.
    Korean J Physiol Pharmacol  2015;35:8866
  8. Autocrine boost of NMDAR current in hippocampal CA1 pyramidal neurons by a PMCA-dependent, perisynaptic, extracellular pH shift.
    Authors: Chen and Chesler
    J Neurosci  2015;35:873
  9. Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function.
    Authors: McGee Et al.
    J Neurosci  2015;35:16171
  10. Characteristics of K(+) Outward Currents in the Cochlear Outer Hair Cells of Circling Mice within the First Postnatal Week.
    Authors: Ahn Et al.
    PLoS One  2015;19:383
  11. Structural elements that underlie Doc2β function during asynchronous synaptic transmission.
    Authors: Xue Et al.
    Proc Natl Acad Sci U S A  2015;112:E4316
  12. Differential Effects of D-Cycloserine and ACBC at NMDA Receptors in the Rat Entorhinal Cortex Are Related to Efficacy at the Co-Agonist Binding Site.
    Authors: Lench Et al.
    Toxins (Basel)  2015;10:e0133548
  13. DA neurons control striatal cholinergic neurons via regionally heterogeneous DA and glutamate signaling.
    Authors: Chuhma Et al.
    Proc Natl Acad Sci U S A  2014;81:901
  14. Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic Mem. treatment in an in vitro model of limbic epileptogenesis.
    Authors: He and Bausch
    BMC Neurosci  2014;77:379
  15. Vort. disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus.
    Authors: Dale Et al.
    J Psychopharmacol  2014;28:891
  16. Mutations that disrupt Ca2+-binding activity endow Doc2β with novel functional properties during synaptic transmission.
    Authors: Gaffaney Et al.
    Mol Biol Cell  2014;25:481
  17. Optogenetic probing and manipulation of the calyx-type presynaptic terminal in the embryonic chick ciliary ganglion.
    Authors: Egawa Et al.
    PLoS One  2013;8:e59179
  18. Ovarian hormone loss impairs excitatory synaptic transmission at hippocampal CA3-CA1 synapses.
    Authors: Wu Et al.
    J Neurosci  2013;33:16158
  19. Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-MthD.-aspartate receptor inhibition.
    Authors: He Et al.
    J Neurosci  2013;109:1535
  20. Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists.
    Authors: Lerner Et al.
    J Neurosci  2010;30:2160
  21. Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex.
    Authors: Toyoda Et al.
    Mol Pain  2009;5:46
  22. Tamox. mediated estrogen receptor activation protects against early impairment of hippocampal neuron excitability in an oxygen/glucose deprivation brain slice ischemia model.
    Authors: Zhang Et al.
    Brain Res  2009;1247:196
  23. Postsynaptic glutamate receptor δ family contributes to presynaptic terminal differentiation and establishment of synaptic transmission.
    Authors: Kuroyanagi Et al.
    J Neurophysiol  2009;106:4912
  24. Glutamatergic transmission is sustained at a later period of development of medial nucleus of the trapezoid body-lateral superior olive synapses in circling mice.
    Authors: Hong Et al.
    J Neurosci  2008;28:13003
  25. Resveratrol attenuates early pyramidal neuron excitability impairment and death in acute rat hippocampal slices caused by oxygen-glucose deprivation.
    Authors: Zhang Et al.
    Exp Neurol  2008;212:44
  26. Coincident glutamatergic and cholinergic inputs transiently depress glutamate release at rat schaffer collateral synapses.
    Authors: Gipson and Yeckel
    J Neurophysiol  2007;97:4108
  27. Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex.
    Authors: Toyoda Et al.
    Mol Pain  2007;3:36
  28. Lack of synapsin I reduces the readily releasable pool of synaptic vesicles at central inhibitory synapses.
    Authors: Baldelli Et al.
    J Neurosci  2007;27:13520
  29. Transient change in GABA(A) receptor subunit mRNA expression in Lurcher cerebellar nuclei during Purkinje cell degeneration.
    Authors: Linnemann Et al.
    Neuron  2006;7:59
  30. Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa.
    Authors: Xu Et al.
    Mol Pain  2006;2:29
  31. N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-MthD.-aspartate receptor activity.
    Authors: Sur Et al.
    Proc Natl Acad Sci U S A  2003;100:13674

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QX-314 bromide blocks action potentials propagation
By Anonymous on 08/17/2019
Species: Rat

QX-314 was used to block voltage-gated sodium channels, i.e. prevent action potential propagation. The compound develops its effect in 1 microM concentration, in use-dependent mode. Figure: EPSC evoked by electrical stimulation in hippocampal pyramidal neuron at positive membrane potential (+40 mV); QX-314 is added to intracellular solution.


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