QX 314 bromide
Chemical Name: N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide
Biological ActivityMembrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels. Intracellular QX 314 bromide also inhibits calcium currents in hippocampal CA1 pyramidal neurons.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine.
Stichartz et al.
QX-314 blocks the potassium but not the sodium dependent components of the opiate response in locus coeruleus neurons.
Alreja and Aghajanian
Brain Res., 1994;639:320
Intracellular QX-314 blocks the hyperpolarization activated inward current Iq in hippocampal CA1 pyramidal cells.
Perkins and Wong
Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons.
Talbot and Sayer
Citations for QX 314 bromide
The citations listed below are publications that use Tocris products. Selected citations for QX 314 bromide include:
32 Citations: Showing 1 - 10
Nucleus Accumbens Tac1-Expressing Neurons Mediate Stress-Induced Anhedonia-like Behavior in Mice
Authors: He Et al.
Cell rep 2020;33
TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala.
Authors: Li Et al.
KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice.
Authors: Spoljaric Et al.
Cell Rep 2019;26:1073
AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP.
Authors: Purkey Et al.
Cell Rep 2018;25:974
Dendrite-Specific Amplification of Weak Synaptic Input during Network Activity In Vivo.
Authors: Ferrarese Et al.
Cell Rep 2018;24:3455
Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain.
Authors: Acuña Et al.
J Clin Invest 2016;126:2547
Enhanced GABAA-Mediated Tonic Inhibition in Auditory Thalamus of Rats with Behavioral Evidence of Tinnitus.
Authors: Sametsky Et al.
J Neurosci 2015;35:9369
Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.
Authors: Puranam Et al.
Korean J Physiol Pharmacol 2015;35:8866
Autocrine boost of NMDAR current in hippocampal CA1 pyramidal neurons by a PMCA-dependent, perisynaptic, extracellular pH shift.
Authors: Chen and Chesler
J Neurosci 2015;35:873
Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function.
Authors: McGee Et al.
J Neurosci 2015;35:16171
Characteristics of K(+) Outward Currents in the Cochlear Outer Hair Cells of Circling Mice within the First Postnatal Week.
Authors: Ahn Et al.
PLoS One 2015;19:383
Structural elements that underlie Doc2β function during asynchronous synaptic transmission.
Authors: Xue Et al.
Proc Natl Acad Sci U S A 2015;112:E4316
Differential Effects of D-Cycloserine and ACBC at NMDA Receptors in the Rat Entorhinal Cortex Are Related to Efficacy at the Co-Agonist Binding Site.
Authors: Lench Et al.
Toxins (Basel) 2015;10:e0133548
DA neurons control striatal cholinergic neurons via regionally heterogeneous DA and glutamate signaling.
Authors: Chuhma Et al.
Proc Natl Acad Sci U S A 2014;81:901
Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic Mem. treatment in an in vitro model of limbic epileptogenesis.
Authors: He and Bausch
BMC Neurosci 2014;77:379
Vort. disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus.
Authors: Dale Et al.
J Psychopharmacol 2014;28:891
Mutations that disrupt Ca2+-binding activity endow Doc2β with novel functional properties during synaptic transmission.
Authors: Gaffaney Et al.
Mol Biol Cell 2014;25:481
Optogenetic probing and manipulation of the calyx-type presynaptic terminal in the embryonic chick ciliary ganglion.
Authors: Egawa Et al.
PLoS One 2013;8:e59179
Ovarian hormone loss impairs excitatory synaptic transmission at hippocampal CA3-CA1 synapses.
Authors: Wu Et al.
J Neurosci 2013;33:16158
Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-MthD.-aspartate receptor inhibition.
Authors: He Et al.
J Neurosci 2013;109:1535
Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists.
Authors: Lerner Et al.
J Neurosci 2010;30:2160
Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex.
Authors: Toyoda Et al.
Mol Pain 2009;5:46
Tamox. mediated estrogen receptor activation protects against early impairment of hippocampal neuron excitability in an oxygen/glucose deprivation brain slice ischemia model.
Authors: Zhang Et al.
Brain Res 2009;1247:196
Postsynaptic glutamate receptor δ family contributes to presynaptic terminal differentiation and establishment of synaptic transmission.
Authors: Kuroyanagi Et al.
J Neurophysiol 2009;106:4912
Glutamatergic transmission is sustained at a later period of development of medial nucleus of the trapezoid body-lateral superior olive synapses in circling mice.
Authors: Hong Et al.
J Neurosci 2008;28:13003
Resveratrol attenuates early pyramidal neuron excitability impairment and death in acute rat hippocampal slices caused by oxygen-glucose deprivation.
Authors: Zhang Et al.
Exp Neurol 2008;212:44
Coincident glutamatergic and cholinergic inputs transiently depress glutamate release at rat schaffer collateral synapses.
Authors: Gipson and Yeckel
J Neurophysiol 2007;97:4108
Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex.
Authors: Toyoda Et al.
Mol Pain 2007;3:36
Lack of synapsin I reduces the readily releasable pool of synaptic vesicles at central inhibitory synapses.
Authors: Baldelli Et al.
J Neurosci 2007;27:13520
Transient change in GABA(A) receptor subunit mRNA expression in Lurcher cerebellar nuclei during Purkinje cell degeneration.
Authors: Linnemann Et al.
Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa.
Authors: Xu Et al.
Mol Pain 2006;2:29
N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-MthD.-aspartate receptor activity.
Authors: Sur Et al.
Proc Natl Acad Sci U S A 2003;100:13674
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QX-314 was used to block voltage-gated sodium channels, i.e. prevent action potential propagation. The compound develops its effect in 1 microM concentration, in use-dependent mode. Figure: EPSC evoked by electrical stimulation in hippocampal pyramidal neuron at positive membrane potential (+40 mV); QX-314 is added to intracellular solution.