QX 314 bromide

  ( 22 citations )    
Product Datasheet
Catalog Number:1014
Chemical Name:N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide
Product Details
Citations (22)
Reviews
Biological Activity
Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels. Intracellular QX 314 bromide also inhibits calcium currents in hippocampal CA1 pyramidal neurons.
Technical Data
  • M.Wt:
    343.31
  • Formula:
    C16H27N2OBr
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    24003-58-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for QX 314 bromide include:

22 Citations: Showing 1 - 10
Filter your results:

  1. Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain.
    Authors: Acuña Et al.
    J Clin Invest  2016;126:2547
  2. Enhanced GABAA-Mediated Tonic Inhibition in Auditory Thalamus of Rats with Behavioral Evidence of Tinnitus.
    Authors: Sametsky Et al.
    J Neurosci  2015;35:9369
  3. Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.
    Authors: Puranam Et al.
    Korean J Physiol Pharmacol  2015;35:8866
  4. Autocrine boost of NMDAR current in hippocampal CA1 pyramidal neurons by a PMCA-dependent, perisynaptic, extracellular pH shift.
    Authors: Chen and Chesler
    J Neurosci  2015;35:873
  5. Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function.
    Authors: McGee Et al.
    J Neurosci  2015;35:16171
  6. Characteristics of K(+) Outward Currents in the Cochlear Outer Hair Cells of Circling Mice within the First Postnatal Week.
    Authors: Ahn Et al.
    PLoS One  2015;19:383
  7. Structural elements that underlie Doc2β function during asynchronous synaptic transmission.
    Authors: Xue Et al.
    Proc Natl Acad Sci U S A  2015;112:E4316
  8. Differential Effects of D-Cycloserine and ACBC at NMDA Receptors in the Rat Entorhinal Cortex Are Related to Efficacy at the Co-Agonist Binding Site.
    Authors: Lench Et al.
    Toxins (Basel)  2015;10:e0133548
  9. Dopamine neurons control striatal cholinergic neurons via regionally heterogeneous dopamine and glutamate signaling.
    Authors: Chuhma Et al.
    Proc Natl Acad Sci U S A  2014;81:901
  10. Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic memantine treatment in an in vitro model of limbic epileptogenesis.
    Authors: He and Bausch
    BMC Neurosci  2014;77:379
  11. Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus.
    Authors: Dale Et al.
    J Psychopharmacol  2014;28:891
  12. Mutations that disrupt Ca2+-binding activity endow Doc2β with novel functional properties during synaptic transmission.
    Authors: Gaffaney Et al.
    Mol Biol Cell  2014;25:481
  13. Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-methyl-D-aspartate receptor inhibition.
    Authors: He Et al.
    J Neurosci  2013;109:1535
  14. Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex.
    Authors: Toyoda Et al.
    Mol Pain  2009;5:46
  15. Postsynaptic glutamate receptor δ family contributes to presynaptic terminal differentiation and establishment of synaptic transmission.
    Authors: Kuroyanagi Et al.
    J Neurophysiol  2009;106:4912
  16. Glutamatergic transmission is sustained at a later period of development of medial nucleus of the trapezoid body-lateral superior olive synapses in circling mice.
    Authors: Hong Et al.
    J Neurosci  2008;28:13003
  17. Coincident glutamatergic and cholinergic inputs transiently depress glutamate release at rat schaffer collateral synapses.
    Authors: Gipson and Yeckel
    J Neurophysiol  2007;97:4108
  18. Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex.
    Authors: Toyoda Et al.
    Mol Pain  2007;3:36
  19. Lack of synapsin I reduces the readily releasable pool of synaptic vesicles at central inhibitory synapses.
    Authors: Baldelli Et al.
    J Neurosci  2007;27:13520
  20. Transient change in GABA(A) receptor subunit mRNA expression in Lurcher cerebellar nuclei during Purkinje cell degeneration.
    Authors: Linnemann Et al.
    Neuron  2006;7:59
  21. Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa.
    Authors: Xu Et al.
    Mol Pain  2006;2:29
  22. N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity.
    Authors: Sur Et al.
    Proc Natl Acad Sci U S A  2003;100:13674
Expand to show all Citations

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used QX 314 bromide?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee