Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+
channels. Intracellular QX 314 bromide also inhibits calcium currents in hippocampal CA1 pyramidal neurons.
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The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine.
Stichartz et al.
QX-314 blocks the potassium but not the sodium dependent components of the opiate response in locus coeruleus neurons.
Alreja and Aghajanian
Brain Res., 1994;639:320
Intracellular QX-314 blocks the hyperpolarization activated inward current Iq in hippocampal CA1 pyramidal cells.
Perkins and Wong
Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons.
Talbot and Sayer
The citations listed below are publications that use Tocris products. Selected citations for QX 314 bromide include:
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