Catalog Number: 1014
Chemical Name: N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide
Biological Activity
Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels. Intracellular QX 314 bromide also inhibits calcium currents in hippocampal CA1 pyramidal neurons.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine.
    Stichartz et al.
    J.Gen.Physiol., 1973;62:37
  2. QX-314 blocks the potassium but not the sodium dependent components of the opiate response in locus coeruleus neurons.
    Alreja and Aghajanian
    Brain Res., 1994;639:320
  3. Intracellular QX-314 blocks the hyperpolarization activated inward current Iq in hippocampal CA1 pyramidal cells.
    Perkins and Wong
    J.Neurophysiol., 1995;73:911
  4. Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons.
    Talbot and Sayer
    J.Neurophysiol., 1996;76:2120

The citations listed below are publications that use Tocris products. Selected citations for QX 314 bromide include:

Showing Results 1 - 10 of 19

  1. Enhanced GABAA-Mediated Tonic Inhibition in Auditory Thalamus of Rats with Behavioral Evidence of Tinnitus.
    Authors: Sametsky Et al.
    J Neurosci
  2. Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.
    Authors: Puranam Et al.
    Korean J Physiol Pharmacol
  3. Autocrine boost of NMDAR current in hippocampal CA1 pyramidal neurons by a PMCA-dependent, perisynaptic, extracellular pH shift.
    Authors: Chen and Chesler
    J Neurosci
  4. Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function.
    Authors: McGee Et al.
    J Neurosci
  5. Characteristics of K(+) Outward Currents in the Cochlear Outer Hair Cells of Circling Mice within the First Postnatal Week.
    Authors: Ahn Et al.
    PLoS One
  6. Structural elements that underlie Doc2β function during asynchronous synaptic transmission.
    Authors: Xue Et al.
    Proc Natl Acad Sci U S A
  7. Differential Effects of D-Cycloserine and ACBC at NMDA Receptors in the Rat Entorhinal Cortex Are Related to Efficacy at the Co-Agonist Binding Site.
    Authors: Lench Et al.
    Toxins (Basel)
  8. Dopamine neurons control striatal cholinergic neurons via regionally heterogeneous dopamine and glutamate signaling.
    Authors: Chuhma Et al.
    Proc Natl Acad Sci U S A
  9. Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic memantine treatment in an in vitro model of limbic epileptogenesis.
    Authors: He and Bausch
    BMC Neurosci
  10. Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus.
    Authors: Dale Et al.
    J Psychopharmacol
  11. Mutations that disrupt Ca2+-binding activity endow Doc2β with novel functional properties during synaptic transmission.
    Authors: Gaffaney Et al.
    Mol Biol Cell
  12. Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-methyl-D-aspartate receptor inhibition.
    Authors: He Et al.
    J Neurosci
  13. Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex.
    Authors: Toyoda Et al.
    Mol Pain
  14. Postsynaptic glutamate receptor δ family contributes to presynaptic terminal differentiation and establishment of synaptic transmission.
    Authors: Kuroyanagi Et al.
    J Neurophysiol
  15. Glutamatergic transmission is sustained at a later period of development of medial nucleus of the trapezoid body-lateral superior olive synapses in circling mice.
    Authors: Hong Et al.
    J Neurosci
  16. Lack of synapsin I reduces the readily releasable pool of synaptic vesicles at central inhibitory synapses.
    Authors: Baldelli Et al.
    J Neurosci
  17. Transient change in GABA(A) receptor subunit mRNA expression in Lurcher cerebellar nuclei during Purkinje cell degeneration.
    Authors: Linnemann Et al.
  18. Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa.
    Authors: Xu Et al.
    Mol Pain
  19. N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity.
    Authors: Sur Et al.
    Proc Natl Acad Sci U S A
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