Recombinant Human ALK-7 Fc Chimera Protein, CF New

Recombinant Human ALK-7 Fc Chimera Protein, CF Summary

Product Specifications

Product Datasheets

Carrier Free

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

Background: ALK-7

Transforming growth Factor beta (TGF-beta ) superfamily ligands exert their biological activities via binding to heteromeric receptor complexes of two types (I and II) of serine/threonine kinases. Type II receptors are constitutively active kinases that phosphorylate type I receptors upon ligand binding. In turn, activated type I kinases phosphorylate downstream signaling molecules including the various smads. Transmembrane proteoglycans, including the type III receptor (betaglycan) and endoglin, can bind and present some of the TGF-beta superfamily ligands to type I and II receptor complexes and enhance their cellular responses. Seven type I receptors (also termed activin receptor like kinase (ALK)) and five type II receptors have been isolated from mammals. ALK -2, -3, -4, -5, and -6 are also known as Activin R1A, BMPR-1A, Activin R1B, TGF-beta R1, and BMPR-1B, respectively, reflecting their ligand preferences. ALK-7 is also known as Activin receptor type-1C, ACTR-1C, and ACVR1C. It shares with other type I receptors a cysteine-rich domain with conserved cysteine spacing in the extracellular region, and a glycine and serine rich domain (the GS domain) preceding the kinase domain. It is primarily expressed in the central nervous system, pancreatic islets, and adipose tissue. ALK-7 known ligands, such as Nodal, Activin B, and growth differentiation factor (GDF), can activate Smads and other signaling pathways which regulate cell proliferation, differentiation, and apoptosis in various cells. It has also been shown that orphan ligand, Activin C, signals through activin receptor-like kinase 7. Meanwhile, in mature murine adipocytes, Activin E invoked a SMAD2/3 response via ALK7, like Activin C.

Related Research Areas

• TGF-beta Family
• TGF-beta Superfamily