Recombinant Human Calsyntenin-2 Protein, CF

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Recombinant Human Calsyntenin-2 Protein, CF Summary

Product Specifications

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Measured by the ability of the immobilized protein to support the adhesion of Neuro‑2A mouse neuroblastoma cells. The ED50 for this effect is 0.7-2.8 μg/mL.
Mouse myeloma cell line, NS0-derived human Calsyntenin-2 protein
Ser21-Thr834, with a C-terminal 6-His tag
Accession #
N-terminal Sequence
Predicted Molecular Mass
92.2 kDa
110-120 kDa, reducing condtitions

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 200 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
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Background: Calsyntenin-2

Calsyntenin-2, also called Alc-gamma (Alcadein-gamma; gene name CLSTN2) is a 120-135 kDa glycoprotein that is a member of the Alcadein family of cadherin domain‑containing type I transmembrane molecules (1, 2). Mature human Calsyntenin-2 is a 935 amino acid (aa) protein with two extracellular cadherin domains. Proteolytic cleavage by ADAM10 and gamma -secretase generates a 105-110 kDa extracellular domain termed soluble alc-gamma, and a 25 kDa, highly acidic, calcium-binding intracellular domain termed Alc gamma ICD (1-3). The soluble alc-gamma portion of human Calsyntenin-2 (aa 21-831) shares 95%, 94%, 96%, 95% and 94% aa identity with mouse, rat, canine, bovine and equine Calsyntenin-2, respectively. A potential isoform variant shows a premature truncation after Gln608. Calsyntenins are predominantly expressed in the ER/Golgi and post-synaptic plasma membranes of neurons (1). While nearly all neurons express Calsyntenin 1, Calsyntenin-2 is mainly found in subpopulations GABAergic  neurons of cortical layers 5 and 6, cerebellum (in Purkinje cells), amygdale (basolateral cells), hippocampus (pyramidal cells and hilus interneurons) and some brain stem neurons (1). Calsyntenin-2 interacts with amyloid precursor protein (APP) through its binding protein, APBA2/X11L, where it is thought to regulate APP cleavage, and likely impacts post-synaptic signaling and gene activation (2, 3). Notably, Alc gamma ICD binds APBA1/FE65 and antagonizes amyloid intracellular domain (AICD) gene activation (3). Polymorphisms of the Calsyntenin-2 gene, in combination with polymorphisms of the brain signaling regulator KIBRA, are thought to modulate episodic memory performance (4, 5).

  1. Hintsch, G. et al. (2002) Mol. Cell Neurosci. 21:393.
  2. Hata, S. et al. (2009) J. Biol. Chem. 284:36024.
  3. Araki, Y. et al. (2004) J. Biol. Chem. 279:24343.
  4. Jacobsen, L.K. et al. (2009) Biol. Psychiatry 65:671.
  5. Preuschhof, C. et al. (2010) Neuropsychologia 48:402.
Entrez Gene IDs
64084 (Human); 64085 (Mouse); 171394 (Rat)
Alternate Names
alcadein gamma; Alcadein-gamma; alcagamma; ALC-GAMMA; cadherin-related family member 13; calsyntenin 2; Calsyntenin2; Calsyntenin-2; CDHR13; CLSTN2; CS2; CS2alcadein-gamma; CSTN2; FLJ39113; FLJ39499; MGC119560


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