Recombinant Human Tau Ladder, CF

R&D Systems | Catalog # SP-505

R&D Systems
Discontinued Product
SP-505 has been discontinued. View all Tau products.

Key Product Details

Source

E. coli

Accession Number

P10636-2, P10636-4, P10636-5, P10636-6, P10636-7, P10636-8

Applications

Bioactivity
View all Tau Proteins and Enzymes »

Product Specifications

Source

E. coli-derived human Tau protein

Purity

>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.

Predicted Molecular Mass

36.8 kDa (0N3R), 39.7 kDa (1N3R), 40.0 kDa (0N4R), 42.6 kDa (2N3R), 43.0 kDa (1N4R) and 45.9 kDa (2N4R)

Activity

Concentration for in vitro assays will depend on experimental conditions and detection methods.

Formulation, Preparation, and Storage

SP-505
Formulation 1.0 mg/ml in PBS pH 7.4, 1 mM DTT
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 24 months from date of receipt, -70 °C as supplied.
  • 3 months, -70 °C under sterile conditions after opening.

Background: Tau

Tau is a microtubule-associated protein expressed primarily in neurons.  Carboxy-terminal domains of Tau associate with and stabilize microtubule structure, while other domains bind to the plasma membrane.  Abnormal Tau phosphorylation may result in the self-assembly of tangles of paired helical and/or straight filaments, which are involved in the pathogenesis of Alzheimer's disease and other neurodegenerative diseases.  Properly folded Tau is highly soluble, but when the protein becomes misfolded it forms insoluble aggregates that can damage cytoplasmic functions, interfere with axonal transport and ultimately lead to cell death.  There are multiple forms of Tau--this product contains equal amounts of the following isoforms:  Tau 352 (0N3R), Tau 381 (1N3R), Tau 383 (0N4R), Tau 410 (2N3R), Tau 412 (1N4R) and Tau 441 (2N4R).  These recombinant proteins are untagged.

References

  1. Billingsley M.L. & Kincaid R.L. (1997) Biochem J.  323: 577
  2. Bloom G.S. (2014) JAMA Neurol.  71: 505
  3. Cripps D. et al. (2006)  J. Biol. Chem.  281: 10825
  4. Harada A. et al. (1994)  Nature  369: 488
  5. Lei P. et al. (2010)  Int. J Biochem Cell Biol.  42: 1775

Long Name

Microtubule-Associated Protein Tau

Alternate Names

MAPT, MSTD, MTBT1, Neurofibrillary tangle protein, PPND

Entrez Gene IDs

4137 (Human); 17762 (Mouse); 29477 (Rat)

Gene Symbol

MAPT

UniProt

P10636-2, P10636-4, P10636-5, P10636-6, P10636-7, P10636-8

Additional Tau Products

Product Documents for Recombinant Human Tau Ladder, CF

Certificate of Analysis

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Product Specific Notices for Recombinant Human Tau Ladder, CF

For research use only

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