Recombinant Human VSTM2B Fc Chimera Protein, CF Summary
Accession # A6NLU5
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 500 μg/mL in PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Recombinant Human VSTM2B Fc Chimera (Catalog # 100060-VT) inhibits IFN-gamma secretion by human peripheral blood mononuclear cells in the presence of anti-CD3 antibody. The ED50 for this effect is 1.5-7.5 μg/mL.
2 μg/lane of Recombinant Human VSTM2B Fc Chimera was resolved with SDS-PAGE underreducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Bluestaining, showing bands at 62-70 kDa and 120 - 140 kDa, respectively.
VSTM2B, or V-set and transmembrane domain-containing protein 2B is a membrane protein which includes a 235 amino acid (aa) extracellular domain that contains an Ig-like V-type domain, a 21 aa transmembrane domain, and one aa in cytoplasm. This extracellular domain shares 45% aa identity human VSTM2A. The mature extracellular domain of human VSTM2B shares 86% and 85% aa sequence identity for the mouse and rat homolog, respectively. Currently, both the expression pattern and biological functions of VSTM2B remain unknown. our in house data show that VSTM2B inhibits the human T cell activation, including anti-CD3 induced IL-2, IFN-gamma secretion, and T cell proliferation.
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