Recombinant Mouse AMIGO2 Fc Chimera (Catalog #9424‑AM) inhibits IL-2 secretion by mouse T cells in the presence of anti-CD3antibody. The ED50 for this effect is 0.3-1.5 μg/mL.
(amphoterin‑induced gene and ORF 2), also known as DEGA and Alivin‑1, is an
approximately 65 kDa transmembrane cell adhesion protein. It belongs to a
family of leucine‑rich repeat (LRR) containing proteins that play various roles
in nervous system development and function (1, 2). Mature mouse AMIGO2 consists
of a 359 amino acid (aa) extracellular domain (ECD) with six LRRs flanked by
single LRRNT and LRRCT domains, followed by one immunoglobulin-like domain, a
21 aa transmembrane segment, and a 101 aa cytoplasmic domain (3-5). Within the
ECD, mouse AMIGO2 shares 89% and 94% aa sequence identity with human and rat
AMIGO2, respectively. AMIGO2 forms homodimers as well as heterodimers with the
related AMIGO1 and AMIGO3 molecules (3, 6). Within the nervous system, AMIGO2
is transcribed in the cerebrum, hypothalamus, olfactory bulb, retina,
hippocampus (pyramidal cells), and cerebellum (granule neurons and Purkinje
cells) (3, 4, 7). It is also expressed in the liver, lung, testis,
spleen, and small intestine (3, 4). AMIGO2 supports neuron survival, and is
down-regulated following pro‑apoptotic stimulation (4). Its expression can be
up‑regulated or down-regulated in a variety of cancers, and anti‑sense
knockdown of AMIGO2 interferes with tumor cell adhesion to collagen as well as in
vivo tumorigenicity (5). AMIGO2 modulates T cell functions and
its deficiency in mice ameliorates experimental autoimmune encephalomyelitis (6).
de Wit, J. et al. (2011) Annu. Rev. Cell Dev. Biol. 27:697.
Chen, Y. et al. (2006) Brain Res. Rev. 51:265.
Kuja-Panula, J. et al. (2003) J. Cell Biol. 160:963.
Ono, T. et al. (2003) J. Neurosci. 23:5887.
Rabenau, K.E. et al. (2004) Oncogene 23:056.
Li, Z., et al. (2017) Brain Behav. Immun. 62:110.
Amphoterin-induced Gene and ORF 2
Entrez Gene IDs:
347902 (Human); 105827 (Mouse)
adhesion molecule with Ig-like domain 2; ALI1amphoterin induced gene 2; alivin 1; Alivin-1; AMIGO2; AMIGO-2; DEGAamphoterin-induced protein 2; differentially expressed in gastric adenocarcinoma; Differentially expressed in gastric adenocarcinomas; transmembrane protein AMIGO2
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