Recombinant Mouse CRELD1 Protein, CF

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R&D Systems Recombinant Proteins and Enzymes
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Recombinant Mouse CRELD1 Protein, CF Summary

Product Specifications

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Measured by its ability to induce adhesion of ATDC5 mouse chondrogenic cells. The ED50 for this effect is typically 0.3-1.5 μg/mL.
Mouse myeloma cell line, NS0-derived mouse CRELD1 protein
Gln30-Glu362, with a C-terminal 6-His tag
Accession #
N-terminal Sequence
No results obtained: Gln30 predicted, sequencing might be blocked
Predicted Molecular Mass
37.1 kDa
50-55 kDa, reducing conditions

Product Datasheets

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 250 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
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Reconstitution Calculator

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Background: CRELD1

Cysteine-rich with EGF-like domain protein 1 (CRELD1) is an approximately 50 kDa transmembrane glycoprotein that contains a 333 amino acid (aa) extracellular domain (ECD), two tandem transmembrane segments, and a second ECD of 15 aa (1). Within the large ECD, mouse and human CRELD1 share 92% aa sequence identity. CRELD1 is widely expressed during development and in the adult (1). It interacts with Reticulon 3/RTN3 and inhibits the pro-apoptotic activity of RTN3 (2). CRELD1 also associates with Adrenergic alpha‑1 receptors in the prostate and limits their expression (3). Missense mutations of human CRELD1 are associated with susceptibility to atrioventricular septal defects in the heart (4). R&D Systems in-house testing indicates that CRELD1 mediates the adhesion of ATDC-5 cells.

  1. Rupp, P.A. et al. (2002) Gene 293:47.
  2. Xiang, R. and S. Zhao (2009) Mol. Cell. Biochem. 331:225.
  3. Nishimune, A. et al. (2010) J. Pharmacol. Sci. 113:169.
  4. Robinson, S.W. et al. (2003) Am. J. Hum. Genet. 72:1047.
Long Name
Cysteine-rich Protein With EGF-like Domains 1
Entrez Gene IDs
78987 (Human); 171508 (Mouse); 312638 (Rat)
Alternate Names
atrioventricular septal defect 2; AVSD2; CIRRIN; CRELD1; cysteine-rich with EGF-like domain protein 1; cysteine-rich with EGF-like domains 1; DKFZp566D213


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