Recombinant Mouse VSIG10 Fc Chimera Protein, CF Summary
Accession # D3YX43
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 200 μg/mL in PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Recombinant Mouse VSIG10 Fc Chimera (Catalog # 9604-VS) inhibits anti-CD3 antibody induced IL-17 secretion in human PBMC. The ED50 for this effect is 0.15-0.9 μg/mL.
VSIG10 (V-set and immunoglobulin domain-containing protein 10) is a single-pass type I membrane protein of the Ig superfamily. Mouse VSIG10 cDNA encodes a 558 amino acid (aa) precursor that contains a 20 aa signal sequence, a 406 aa extracellular domain (ECD), a 21 aa transmembrane sequence, and a 111 aa cytoplasmic domain (1). The ECD of mouse VSIG10 contains four Ig-like C2-type domains and shares 63% and 84% aa identity with human and rat VSIG10, respectively. The specific biological function of VSIG10L has yet to be elucidated, but there is evidence to suggest the molecule is involved in cell-cell adhesion. Ig‑like C2-type domains are similar to antibody constant domains and can be found in T cell adhesion molecules, such as Cluster of Differentiation 2 (CD2) along with vascular and intercellular cell adhesion molecules (VCAM and ICAM, respectively) (2). VSIG10 is structurally related to the B7 family of immune regulatory proteins. Our studies at R&D Systems show that VSIG10 inhibits T cell activation, including IL-17 and Interferon gamma production.
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