Chemical Name: 3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione
Biological ActivityRI 1 is a RAD51 inhibitor (IC50 is in the range 5 - 30 μM). Covently binds C139 on protein surface. Inhibits homologous recombination. Cell permeable. Sensitizes tumor cells to chemotherapy.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells.
Budke et al.
Nucleic Acids Res., 2012;40:7347
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