RI 1

Catalog # Availability Size / Price Qty
6168/10
6168/50
RI 1 | CAS No. 415713-60-9 | DNA, RNA and Protein Synthesis Inhibitors
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Description: RAD51 recombinase inhibitor

Chemical Name: 3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione

Purity: ≥98%

Product Details
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Biological Activity

RI 1 is a RAD51 inhibitor (IC50 is in the range 5 - 30 μM). Covently binds C139 on protein surface. Inhibits homologous recombination. Cell permeable. Sensitizes tumor cells to chemotherapy.

Technical Data

M.Wt:
361.61
Formula:
C14H11Cl3N2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
415713-60-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells.
    Budke et al.
    Nucleic Acids Res., 2012;40:7347

Product Datasheets

Reconstitution Calculator
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Reconstitution Calculator

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