RI 1

Catalog #: 6168 Datasheet / COA / SDS

Discontinued Product

6168 has been discontinued.
View all DNA, RNA and Protein Synthesis Inhibitors products.
RI 1 | CAS No. 415713-60-9 | DNA, RNA and Protein Synthesis Inhibitors
1 Image
Description: RAD51 recombinase inhibitor

Chemical Name: 3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione

Purity: ≥98%

Product Details

Biological Activity

RI 1 is a RAD51 inhibitor (IC50 is in the range 5 - 30 μM). Covently binds C139 on protein surface. Inhibits homologous recombination. Cell permeable. Sensitizes tumor cells to chemotherapy.

Technical Data

Soluble to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells.
    Budke et al.
    Nucleic Acids Res., 2012;40:7347

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).


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