Catalog Number: 0415
Chemical Name: 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone
Biological Activity
Widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM). Also available as part of the Phosphodiesterase Inhibitor Tocriset™.
Technical Data
  • M.Wt:
    278.35
  • Formula:
    C15H22N2O3
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    29925-17-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes.
    Nicholson et al.
    TiPS, 1991;12:19
  2. The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle.
    Reeves et al.
    Biochem.J., 1987;241:535
  3. Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase.
    Soderling et al.
    Proc.Natl.Acad.Sci.U.S.A., 1998;95:8991
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ro 20-1724 include:

1 Citations: Showing 1 - 1

  1. Rapid remodeling of tight junctions during paracellular diapedesis in a human model of the blood-brain barrier.
    Authors: Winger Et al.
    J Immunol 2014;193:2427

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