Ro 32-0432 hydrochloride

Key Product Details

Product Description

Ro 32-0432 hydrochloride is a selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca²⁺ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α, βΙ, βΙΙ, γ and ε respectively. Orally available and prevents T cell chronic inflammation in vivo.

Product Specifications for Ro 32-0432 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Ro 32-0432 hydrochloride

The following data is based on the product molecular weight 489.01.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.45 mL	102.25 mL	204.49 mL
0.5 mM	4.09 mL	20.45 mL	40.90 mL
1 mM	2.04 mL	10.22 mL	20.45 mL
5 mM	0.41 mL	2.04 mL	4.09 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Birchall Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation. J.Pharmacol.Exp.Ther. 1994 PMID: 8114006
• Wilkinson Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem.J. 1993 PMID: 8373348

Product Documents for Ro 32-0432 hydrochloride