Catalog Number: 1587
Chemical Name: 3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride
Biological Activity
Selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α, βΙ, βΙΙ, γ and ε respectively. Orally available and prevents T cell chronic inflammation in vivo.
Technical Data
  • M.Wt:
    489.01
  • Formula:
    C28H28N4O2.HCl
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    151342-35-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation.
    Birchall et al.
    J.Pharmacol.Exp.Ther., 1994;268:922
  2. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C.
    Wilkinson et al.
    Biochem.J., 1993;294:335
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ro 32-0432 hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo.
    Authors: Signore Et al.
    Cell Death Dis 2014;5:e1223
  2. Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death.
    Authors: Robert Et al.
    PLoS One 2009;4:e7889

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