Selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca2+
and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α
respectively. Orally available and prevents T cell chronic inflammation in vivo
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All Tocris products are intended for laboratory research use only.
Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation.
Birchall et al.
Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C.
Wilkinson et al.
The citations listed below are publications that use Tocris products. Selected citations for Ro 32-0432 hydrochloride include:
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