Ro 32-0432 hydrochloride

Catalog # Availability Size / Price Qty
1587/1
Ro 32-0432 hydrochloride | CAS No. 1781828-85-0 | Protein Kinase C Inhibitors
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Description: Potent, orally active PKC inhibitor

Chemical Name: 3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride

Purity: ≥99%

Product Details
Citations (2)
Reviews

Biological Activity

Selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α, βΙ, βΙΙ, γ and ε respectively. Orally available and prevents T cell chronic inflammation in vivo.

Technical Data

M.Wt:
489.01
Formula:
C28H28N4O2.HCl
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
1781828-85-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Ro 32-0432 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Ro 32-0432 hydrochloride include:

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